| 全基因组关联在研究疟原虫耐药基因中的应用 |
| |
| 引用本文： | 宋艳辉,周有良,陈佩琴,孟哲峰.全基因组关联在研究疟原虫耐药基因中的应用[J].中国热带医学,2013,13(1):117-120. |
| |
| 作者姓名： | 宋艳辉 周有良 陈佩琴 孟哲峰 |
| |
| 作者单位： | 1. 江苏国际旅行卫生保健中心苏州分中心传染病监测实验室,江苏苏州,215011
2. 复旦大学附属公共卫生临床中心,上海,201508 |
| |
| 摘 要： | 疟原虫多重耐药性的出现以及日趋扩散的耐药形势成为在疟疾防治工作中的最大挑战。新近发展起来的全基因组关联研究（Genome-wide association studies,GWAS）已经广泛应用于多种复杂疾病或性状易感基因分析的工作中。GWAS提供了一种高通量的在全基因组范围内筛选疟原虫耐药基因的强有力的工具,能够进一步明确耐药机制并指导合理用药。本文对GWAS在疟原虫耐药基因分析中的应用进行初步探讨,以期为疟原虫耐药性基因的研究提供参考。
|
| 关 键 词： | 全基因组关联研究 疟原虫 耐药基因位点 |
Application of genome-wide association study in analysis of Plasmodium drug-resistance Gene |
| |
| Institution: | SONG Yan-hui, ZHOU You-liang, CHEN Pei-qin, et al.(1.1nfectious Disease Monitoring Lab, Jiangsu International Travel Healthcare Center, Suzhou Branch, Suzhou 215011,Jiangsu, ; 2. Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508,P. R. China; Corresponding author,SONG Yna-hui, E-mail ：syh430071@yahoo.com.cn) |
| |
| Abstract: | The emergence and spreading of Plasmodium multi-drug resistance now become the biggest challenge in prevention and control of malaria. The recently developed genome-wide association studies （GWAS） has been widely used in a variety analysis of susceptibility genes related to complex diseases or traits. GWAS provides us with a powerful tool for a high-throughput screening of Plasmodium drug-resistance genes in the genome-wide range. In that way, we can further clarify the mechanisms of drug-resistance and guide using of drug rationally. In this article, the application of GWAS in Plasmodium drug-resistance genes analysis was discussed to provide potential evidences for investigation of drug-resistance genes of Plasmodium. |
| |
| Keywords: | Genome-wide association studies Plasmodium drug resistance loci |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
