青中年急性脑梗死颈动脉粥样硬化斑块与hs-CRP的相关性

目的探讨中青年急性脑梗死患者颈动脉粥样硬化斑块性质与高敏C-反应蛋白（hs-CRP）之间的关系。方法对海南省农垦总局医院确诊中青年急性脑梗死92例住院患者和同期住院的非脑血管病患者90例分别应用高频多普勒超声检测颈动脉斑块,同时采用全自动化仪分别检测其血hs-CRP浓度;将脑梗死组依斑块性质分为不稳定斑块组、稳定斑块组及无斑块组,非脑血管病为对照组,对所检测结果分析各组间的检出率和颈动脉粥样硬化斑块类型与hs-CRP相关性。结果青中年急性脑梗死患者的斑块检出率明显高于对照组（P〈0.01）,不稳定斑块组明显高于稳定斑块组及无斑块组（P〈0.01）,稳定斑块组高于无斑块组（P〈0.01）,脑梗死3个亚组中,不稳定斑块组hs-CRP水平明显高于稳定斑块组及无斑块组（P〈0.05）,稳定斑块组hs-CRP水平高于无斑块组（P〈0.05）。结论青中年急性脑梗死患者hs-CRP水平及颈动脉斑块有其相关性,尤其与不稳定斑块密切相关。

Correlation of hs-CRP level with carotid atherosclerotic plaque in young adult patients with acute cerebral infarction

Objective To investigate the relationship between carotid atherosclerotie plaque and High-sensitivity C-reactive protein （hs-CRP） level in young adult patients with acute cerebral infarction. Methods The carotid atheroselerosis in 90 non-cerebrovascular disease inpatients （control group） and 92 acute cerebral infarction inpatients of young and middle age group （Observation group） diagnosed in Hainan Nongken General hospital were determined by high frequency Doppler ultrasound. The levels of hs-CRP were detected by the fully automated instrument. Cerebral infarction （CI）group was divided into unstable plaque group and stable plaque group. The results were compared between the two groups..The relationship of carotid atherosclerotic plaque type and the level of hs-CRP were investigated. Results The plaque detection rate in inpatients with acute cerebral infarction was significantly higher than the healthy group（P〈0.01 ）and that the unstable plaque group was higher than that of the stable plaque group （P〈0.01）.The level of hs-CRP in inpatients with acute cerebral infarction was significantly higher than those in control Group（P〈0.01 ）. The level of hs-CRP in unstable plaque group was significantly higher than the stable plaque and no plaque group （P〈0.05）. Conclusions Hs-CRP levels in young-and-middle-aged CI inpatients is associated with those without or without carotid artery plaque, especially in those having unstable plague.