239例尿路感染革兰阴性菌的菌株分布及耐药性分析

目的分析尿路感染病原菌分布及耐药性特点,为临床提供可靠的诊断和治疗依据。方法对2010年8月~2011年11月期间就诊的疑似尿路感染患者进行中段尿细菌培养和药物敏感试验。结果在分离的239株革兰阴性菌中,以大肠埃希菌为主,其次是铜绿假单胞菌和肺炎克雷伯菌。所测菌株对亚胺培南、美罗培南和哌拉西林/他唑巴坦的耐药率较低,分别为3.8%、6.0%和14.3%。大肠埃希菌和肺炎克雷伯菌产ESBLs株分别为83株和6株,阳性率分别为68%和30%。结论尿路感染的革兰阴性病原菌分布广泛,不同的革兰阴性菌对各类抗菌药物的耐药性存在差异,临床医生应根据药敏结果合理使用抗生素。

Distribution and drug resistance of 239 gram-negative bacteria causing urinary tract infections

Objective To survey the distribution and resistant characteristic of pathogens in urinary infection. Methods Distribution and drug resistance of pathogens in 239 culture-positive urinary tract infection patients from Aug 2010 to Nov 2011 were analyzed. Results A total of 239 strains of Gram negative bacteria were collected, The first frequent bacteria was Escherichia coli. followed by Pseudomonas aeruginosa and Klebsiella pneumoniae the resistant rates of the gram negative bacilli to imipenem, meropenem and piperacillin/tazobactam were 3.8%, 6.0% and 14.3%, respectively. ESBLs producing Escherichia coli and Klebsiella pneumoniae was 68.0% and 30.0% ,resectively.Conclusion Distribution of gram-negative bacteria causing urinary tract infections is wide,the antimierobial resistance of Gram negative bacilli is different, the antibiotics for clinical treatment of patients with urinary tract infection should be used rationally according to the result of susceptibility test.