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| 子宫内膜癌中E2F-1和Survivin的表达及相关性 | |
| 引用本文： | 张娟,王琰,杨华英,时志民,孙杰,张巍,司军英.子宫内膜癌中E2F-1和Survivin的表达及相关性[J].中国热带医学,2013,13(2):192-194. |
| 作者姓名： | 张娟 王琰 杨华英 时志民 孙杰 张巍 司军英 |
| 作者单位： | 1. 邯郸市妇幼保健院,河北邯郸,056002 2. 河北省邯郸市中医院,河北邯郸,056002 3. 河北工程大学医学院,河北邯郸,056001 4. 邯郸市中心医院,河北邯郸,056001 |
| 基金项目： | 河北省教育厅自然科学青年基金 |
| 摘 要： | 目的检测子宫内膜癌组织中E2F-1和Survivin表达情况并探讨其意义。方法采用免疫组织化学S-P法检测60例子宫内膜癌、32例正常子宫内膜组织中两者的表达。结果子宫内膜癌组织中E2F-1和Survivin表达定位于细胞核,其阳性表达率分别为58.33%（35/60）和55.00%（33/60）,均明显高于正常子宫内膜组织0和0（P〈0.05）。两者的表达与有无淋巴结转移、浸润深度、临床分期及病理分期有关（P〈0.05）;通过相关性分析E2F-1和Survivin在子宫内膜癌组织中呈正相关（P〈0.05）。结论 E2F-1和Survivin在子宫内膜癌呈成过度表达,两者共同作用参与子宫内膜癌的发生、发展及转移。 |
| 关 键 词： | 子宫内膜肿瘤 E2F-1 Survivin 免疫组化 |
Expression and significance of E2F-1 and survivin in endometrial carcinoma |
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| Institution: | ZHANG Juan,WANG Yan, YANG Hua-ying et al. ( Handan Municipal Maternal and Child Health Hosphal,Handan 056002,Hebei,P. R. China) |
| Abstract: | Objective To determine the expression of E2F-1 and survivin in the endometrial carcinoma and the significance. Methods The expressions of E2F-1 and survivin in 60 endometzial cancer cases and 32 normal endometrial tissue were determined by immunohistochemistry S-P. Results The positive rates of expressions of E2F-1 and survivin were 58.33%（35/60）and 75.00%（45/60）,significandy higher than that of normal endometrial tissue （P〈0.05）. The expressions of E2F-1 and survivin were associated with myometrial invasion,lymph node metastasis,clinical phase and pathological staging（P〈0.05）.In endometrial carcinoma,the expressions of E2F-1 and Survivin were positively correlated with each other （P〈0.05）. Conclusions E2F-1 and Survivin were highly expressed in the endometrial caneinoma cases and their expressions were assoieated with endometrial carcinoma the development and the metastasis. |
| Keywords: | Endometrial carcinoma E2F-1 Survivin Immunohistochemistry |
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