西非209例中国人恶性疟临床分析

目的探讨近年到西非的中国人感染恶性疟的临床特点及治疗方法。方法收集西非国家209例实验室确诊的中国人恶性疟病例,对其临床表现、实验室检查结果、治疗方案及效果进行回顾性分析。结果209例恶性疟临床表现不典型、复杂多样,可伴有头痛、咽痛、肌肉痛、怠倦等症候群、咳嗽、咳痰等呼吸道症状以及腹痛、腹泻、呕吐等消化道症状,采用青蒿素衍生物和奎宁类药物早期、联合、分级、系统抗疟治疗后症状均消失,无恶性疟重症病例发生,仅3例实验室复查仍有少量疟原虫,成为无症状带虫者。结论恶性疟临床表现复杂多样,疟疾高发区应予给高度重视和警惕,早期、联合、分级、系统抗疟治疗效果满意,可以有效减少和避免重症恶性疟的发生。

Analysis of 209 Chinese falciparum malaria patients in West Africa

Objective To observe clinical manifestation and therapy of the Chinese patients with Plasmodium falciparum malaria in West Africa.Methods A total of 209 Chinese cases with Plasmodium falciparum malaria diagnosed by laboratory examination were collected in West Africa,their clinical manifestations,results of laboratory examination and treatment were retrospectively analyzed.Results The clinical manifestation of 209 Chinese cases with Plasmodim falciparum malaria were not typical,complicated various,accompanied with headache,pharyngalgia,muscle ache,and lethargy symptoms etc.,cough and expectoration of respiratory symptoms etc.,abdominal pain,diarrhea,and vomiting of digestive tract symptoms etc.,early,combined,grade,and system using arteannuines derivatives and type of quinine medicine,the clinical manifestations disappeared after antimalarial treatment,without cases of Plasmodium falciparum malaria,only 3 cases were found a few Plasmodium by laboratory review testing,who became carriers without symptoms.Conclusion The clinical manifestation of Plasmodium falciparum malaria were complicated,the malaria high area should be focused and bewared,the effects of early,combined,grade,and system antimalarial treatment were satisfied,which can effectively reduce and avoid falciparum malaria.