Mapping Quantitative Trait Loci for Circadian Behavioral Rhythms in SMXA Recombinant Inbred Strains |
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| Authors: | Tohru Suzuki Akira Ishikawa Masahiko Nishimura Takashi Yoshimura Takao Namikawa Shizufumi Ebihara |
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| Affiliation: | (1) Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, 464-8601, Japan;(2) Division of Genetics and Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, 464-8601, Japan;(3) Institute for Laboratory Animal Research, Nagoya University School of Medicine, Nagoya, 466-8550, Japan |
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| Abstract: | SM/J and A/J inbred strain of mice have different characteristics in circadian behaviors such as free-running period ( ), phase relationship ( ) between light-dark cycles and activity rhythms, and amount of wheel-running activity. To determine the genes which affect these behaviors, a quantitative trait locus (QTL) analysis using SMXA recombinant inbred strains derived from SM/J and A/J mice was performed. Concerning , two regions on chromosomes (Chrs) 7 and 18 surpassed the genome-wide suggestive level. As for , one suggestive QTL was detected on Chr 7. The QTLs which affect daily activity counts under light-dark cycles and constant darkness were mapped to the same chromosomal regions on Chrs 1 and 17, respectively. The provisional QTLs detected in the present study might be useful for understanding the complex mechanism regulating circadian behaviors. |
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| Keywords: | SM/J mice A/J mice SMXA recombinant inbred strains quantitative trait locus circadian rhythm |
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