新疆地区维吾尔族和汉族溃疡性结肠炎危险因素的分析

背景:溃疡性结肠炎(UC)的发病在不同地区和民族之间存在差异,其发病率逐年增高,但发病原因至今仍不十分明确。目的:探讨新疆地区维吾尔族和汉族UC发病可能的危险因素。方法:纳入经结肠镜检查和病理活检确诊的93例初发型UC患者,其中维吾尔族患者46例,汉族患者47例,同时选择匹配的健康人作为对照。行问卷调查,对可能与UC发病相关的11个变量行单因素分析,差异有统计学意义的变量进一步行多因素条件logistic回归分析。结果:单因素分析显示:油腻饮食、阑尾切除、肠道感染、精神紧张、牛奶摄入与维吾尔族人群UC的发病相关(P<0.05);而吸烟、辛辣饮食、阑尾切除、肠道感染、精神紧张、牛奶摄入与汉族人群UC的发病相关(P<0.05)。多因素条件logistic回归分析显示:油腻饮食(OR=1.970,95%CI:1.412～2.785,P=0.000)、偶尔和经常牛奶摄入(OR=3.219,95%CI:1.190～8.567,P=0.005;OR=2.375,95%CI:1.024～6.649,P=0.004)可能是维吾尔族人群UC发病的危险因素;精神紧张(OR=1.975,95%CI:1.032～3.469,P=0.025)、经常牛奶摄入(OR=4.291,95%CI:1.418～11.913,P=0.012)可能是汉族人群UC发病的危险因素,而吸烟可能是保护因素(OR=0.076,95%CI:0.015～0.527,P=0.004)。结论:新疆地区维吾尔族和汉族UC的发病危险因素可能存在差异,对于维吾尔族人群,油腻饮食、牛奶摄入可能是UC发病的危险因素;而精神紧张、经常牛奶摄入可能是汉族人群UC发病的危险因素,吸烟可能是保护因素。

Analysis of Risk Factors of Ulcerative Colitis in Uygur and Han Populations in Xinjiang

Background： Incidence of ulcerative colitis （UC） is different among different areas and nations, and is increasing year by year, however, its pathogenesis is still not fully clear. Aims： To investigate the possible risk factors of UC in Uygur and Han populations in Xinjiang. Methods： Ninety-three patients with initial UC diagnosed by colonoscopy and biopsy were enrolled, including 46 Uygnr patients and 47 Han patients. Matched Uygur and Han normal persons were served as controls. A questionnaire was conducted, and 11 suspected variables were screened by univariate analysis and those with statistical significance were further analyzed by multivariate conditional logistic regression. Results： Univariate analysis showed that oily food, appendectomy, intestinal infection, mental stress, milk intake were associated with Uygnr UC patients （ P 〈 0.05 ） ; smoking, spicy food, appendectomy, intestinal infection, mental stress, milk intake were associated with Han UC patients （ P 〈 0.05 ）. Multivariate conditional logistic regression analysis showed that oily food （ OR = 1. 970, 95% CI： 1. 412-2.785, P =0.000）, occasional and plenty of milk intake （OR = 3. 219, 95% CI： 1. 190-8. 567, P = O. 005 ; OR = 2.375, 95% CI ： 1. 024-6.649, P = 0. 004） were risk factors for Uygur UC patients, while mental stress （0R=1.975, 95% CI： 1.032-3.469, P=0.025） and plenty of milk intake （0R=4.291,95% CI： 1.418-11.913, P = 0. 012） were risk factors for Han UC patients, smoking might be the protective factor （ OR = 0.076, 95% CI ： 0. 015- 0.527, P = 0. 004）. Conclusions： The risk factors of UC in Uygur and Han patients may be different. For Uygnr population, oily food and milk intake may be the risk factors for UC, while mental stress and plenty of milk intake may be the risk factors for UC in Han population, and smoking may be a protective factor.