766例IBD住院患者的人口资料分析

背景:炎症性肠病(IBD)是一种病因未明且反复发作的慢性炎性肠道疾病,包括克罗恩病(CD)和溃疡性结肠炎(UC)。近年我国IBD的发病率呈逐年上升趋势。目的:回顾性分析IBD患者的人口资料。方法:回顾性分析2002年7月～2011年6月上海瑞金医院766例IBD住院患者的性别、年龄、居住地、家族聚集性等人口资料。结果:IBD的发病率呈逐年上升趋势。CD和UC患者的男女比分别为2.02∶1和1.36∶1。CD患者确诊时的平均年龄明显低于UC患者[(33.30±14.76)岁对(40.10±17.55)岁,P<0.0001]。CD患者发病高峰年龄较UC早。IBD城市患者多于农村患者。1.14%的CD患者和1.68%的UC患者存在家族史。结论:2002～2011年间IBD的新发例数呈明显上升趋势,且CD发病率的增幅明显大于UC;CD和UC患者均以男性多见;UC患者平均诊断年龄高于CD患者,两组IBD患者均未见明显年龄双高峰;CD和UC以城市患者多见,且均缺乏家族聚集性特征。

Demographic Analysis of 766 In-patients with IBD

Background： Inflammatory bowel disease （IBD） is a group of chronic relapsing inflammatory intestinal disease with unknown etiology, comprising Crohn＇s disease （CD） and ulcerative colitis （UC）. The incidence of IBD is increasing in China year by year. Aims ： To retrospectively analyze the demographic data of IBD patients. Methods ： Demographic data including gender, age, residence and familial aggregation of 766 IBD in-patients from July 2002 to June 2011 at Shanghai Ruijin Hospital were retrospectively analyzed. Results： The incidence of IBD was increased during the past 9 years. The ratio of male to female in CD and UC was 2.02：1 and 1.36： 1, respectively. The average onset age was significantly lower in CD than in UC [ （33.30± 14.76） years vs. （40.10 ± 17.55） years, P 〈0.0001 ]. The peak age of CD was younger than UC. The patients with IBD from urban area were more common than from rural area. 1.14% of CD and 1.68% of UC had family history. Conclusions： The incidence of IBD is increased during the past 9 years. The crescendo increase of CD incidence is greater than that of UC. The ratio of male to female in IBD patients shows a male predominance. The average age of UC is elder than CD, and there is no bimodal age distribution. The IBD patients from urban area are more common, and familial aggregation is not obvious.