Evidence for a Physiologic Role of Erythropoietin in Fetal Erythropoiesis |
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| Authors: | Zanjani, Esmail D. Mann, Leon I. Burlington, Harold Gordon, Albert S. Wasserman, Louis R. |
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| Affiliation: | 1 Departments of Physiology and Medicine, Mount Sinai School of Medicine of the CityUniversity of New York, New York, N.Y. 10029; Department of Obstetrics and Gynecology, NassauCounty Medical Center and Health Sciences Center, Stony Brook, N.Y. 11790; and Department ofBiology, New York University, New York, N.Y. 10003.
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| Abstract: | Administration of antibody prepared inrabbits against human urinary Ep to fetalsheep during the last third of the gestation period resulted in a suppression oferythropoiesis in the fetus. This wasevidenced by a sharp decrease in the numbers of circulating reticulocytes and a reduced rate of 59Fe incorporation into RBC,spleen, and bone marrow, effects ascribable to a neutralization of endogenous Ep.In addition, there was a significant decrease in the numbers of nucleated erythroid cells in the bone marrows of thesefetuses. These results point to a physiologic role for Ep in fetal erythropoiesis. Submitted on December 17, 1973 Revised on February 19, 1974 Accepted on February 20, 1974 |
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