DNA binding specificity of the Arc and Mnt repressors is determined by a short region of N-terminal residues. |
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| Authors: | K L Knight and R T Sauer |
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| Affiliation: | Department of Biology, Massachusetts Institute of Technology, Cambridge 02139. |
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| Abstract: | The Arc and Mnt repressors of phage P22 are related proteins that bind to different operator DNA sites. By creating a hybrid Arc-Mnt protein, we show that the binding specificity of Mnt can be switched to that of Arc by replacing six residues at the N terminus of Mnt with the corresponding nine residues from Arc. |
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