| 皮肤成纤维细胞在创面愈合中的研究进展 |
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| 引用本文： | 何秀娟,林燕,刘青武,陈佳,李萍. 皮肤成纤维细胞在创面愈合中的研究进展[J]. 中华损伤与修复杂志, 2021, 0(1): 74-77 |
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| 作者姓名： | 何秀娟 林燕 刘青武 陈佳 李萍 |
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| 作者单位： | 首都医科大学附属北京中医医院 |
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| 基金项目： | 国家自然科学基金项目(81774312,81774328,81804093)。 |
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| 摘 要： | 皮肤成纤维细胞是参与创面愈合的主要修复细胞,近年来其异质性及其与周围细胞间的通讯正逐渐引起重视.真皮成纤维细胞亚群主要包括乳头状成纤维细胞和网状成纤维细胞,对创面愈合发挥不同的作用.成纤维细胞通过自分泌和旁分泌信号分子与周围细胞之间相互作用构成创面微环境,影响创面愈合.慢性创面中的成纤维细胞表现出多种功能障碍.本文就成...
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| 关 键 词： | 伤口愈合 成纤维细胞 皮肤 |
Research progress of skin fibroblasts in wound healing |
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| He Xiujuan,Lin Yan,Liu Qingwu,Chen Jia,Li Ping. Research progress of skin fibroblasts in wound healing[J]. Chinese Journal of Injury Repair and Wound Healing, 2021, 0(1): 74-77 |
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| Authors: | He Xiujuan Lin Yan Liu Qingwu Chen Jia Li Ping |
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| Affiliation: | (Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing Institute of Traditional Chinese Medicine,Beijing 100010,China) |
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| Abstract: | The skin fibroblasts are the main repair cells involved in wound healing.In recent years,their heterogeneity and their communication with nearby cells have gradually attracted attention.The subgroups of dermal fibroblasts mainly include papillary fibroblasts and reticular fibroblasts,which play different roles in wound healing.The fibroblasts interact with nearby cells through autocrine and paracrine signal molecules to form the wound microenvironment,which affects wound healing.The fibroblasts in chronic wounds show a variety of dysfunctions.This article reviews the origin,phenotype,communication with nearby cells of fibroblasts and their dysfunction in chronic wounds. |
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| Keywords: | Wound healing Fibroblasts Skin |
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