美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的效果

目的探讨美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的效果。方法回顾性分析2018年1月至2020年1月本院收治的100例溃疡性结肠炎患者的临床资料,根据治疗方法将患者分为单独治疗组(n=50,美沙拉嗪单独治疗)与联合治疗组(n=50,美沙拉嗪联合双歧杆菌三联活菌治疗)。比较两组患者的临床疗效、血清炎性因子水平、免疫功能。结果联合治疗组的治疗总有效率高于单独治疗组(P<0.05)。治疗后,两组的血清IL-6、IL-8、hs-CRP及TNF-α水平均降低,且联合治疗组低于单独治疗组(P<0.05)。治疗后,两组的血清IgA、IgG、IgM水平、CD8+均降低,CD3+、CD4+及CD4+/CD8+均升高,且联合治疗组优于单独治疗组(P<0.05)。结论相较于美沙拉嗪单独治疗,美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的效果更显著。

Effect of mesalazine combined with Bifidobacterium triple viable bacteria in the treatment of ulcerative colitis

Objective To explore the effect of mesalazine combined with Bifidobacterium triple viable bacteria in the treatment of ulcerative colitis.Methods The clinical data of 100 patients with ulcerative colitis admitted in our hospital from January 2018 to January 2020 were retrospectively analyzed.According to the treatment methods,the patients were divided into single treatment group(n=50,mesalazine alone treatment)and combined treatment group(n=50,mesalazine combined with Bifidobacterium triple viable bacteria treatment).The clinical efficacy,serum inflammatory factor levels and immune function of the two groups were compared.Results The total effective rate of treatment in the combined treatment group was higher than that in the single treatment group(P<0.05).After treatment,the serum IL-6,IL-8,hs-CRP and TNF-αlevels in the two groups decreased,and those in the combined treatment group were lower than the single treatment group(P<0.05).After treatment,the levels of serum IgA,IgG,IgM and CD8+in the two groups decreased,while CD3+,CD4+and CD4+/CD8+increased,and those in the combined treatment group were better than the single treatment group(P<0.05).Conclusion Compared with mesalazine alone treatment,the mesalazine combined with Bifidobacterium triple viable bacteria in the treatment of ulcerative colitis has more significant effect.