粪肠球菌预测结直肠癌复发的研究

目的 探索结直肠癌患者粪便样本中粪肠球菌丰度对于患者复发的预测意义.方法 选取哈尔滨医科大学附属第四医院普外科结直肠癌复发患者与非复发患者的粪便样本共103例,通过16 s测序技术寻找差异的肠道菌群,通过统计学分析探索差异菌群与患者临床病理学指标及无复发生存之间的关系.结果 粪肠球菌在复发患者粪便组织中丰度更高;粪便样...

Fecal Enterococcus faecalis for prediction of recurrence in colorectal cancer

Objective To explore the significance of the abundance of enterococcus faecalis in the prediction of recurrence in patients with colorectal cancer.Methods All The 103 fecal samples were collected from patients with recurrent colorectal cancer and non-recurrent colorectal cancer at the deparment of general surgery in the fourth affiliated hospital of Harbin Medical University.16S sequencing technology was used to search for different intestinal flora.Statistical analysis was used to explore the relationship between different flora and clinical pathological indicators of patients and relapse-free survival.Results Enterococcus faecalis in patients with recurrent organization is higher abundance in stool samples,the patients who have higher abundance in stool samples has more pathological indicators of poor prognosis,meanwhile we also find that high abundance of dung enterococcus in patients have shorter total survival time and shorter relapse-free survival.Conclusion The abundance of Enterococcus faecalis in fecal samples may be a new marker to judge the prognosis of patients with colorectal cancer in the future.