影像组学评估进展期胰腺癌化疗敏感性及预后

目的:探讨影像组学对进展期胰腺癌(Advanced pancreatic cancer,APC)化疗敏感性和预后的评估价值.方法:回顾性分析经病理证实的114例患者的CT增强及形态学特征,采用AnalysisKit软件提取胰腺实质期APC纹理特征参数,采用R语言进行特征筛选,采用Logistic回归模型及Cox比例风险...

Radiomics evaluation of chemosensitivity and prognosis of advanced pancreatic cancer

Objective:To explore the value of imaging histology in evaluating the chemosensitivity and prognosis of advanced pancreatic cancer(APC).Methods:CT enhancement and morphological features of 114 patients proved pathologically were analyzed retrospectively.APC texture feature parameters in pancreatic parenchymal phase were extracted by AnalysisKit software.Feature screening was performed by R language.Logistic regression model and Cox proportional hazards model were used to evaluate chemotherapy sensitivity and prognosis survival time of APC patients.Results:In predicting chemosensitivity,the area under the curve(AUC)of imaging features is superior to clinical features,with AUC of 0.914(95%CI:0.862,0.965),0.728(95%CI:0.639,0.816),P=0.0001 respectively.In predicting the survival time of prognosis,the combined imaging and clinical features are superior to those based on clinical features only.The C-index of the regression model established is0.692(95%CI:0.640,0.743),0.608(95%CI:0.551,0.665),P=0.003 respectively.Conclusion:Imaging histology has good clinical value in evaluating the chemosensitivity and prognosis of APC.