应用三维斑点追踪成像评价高尿酸血症对高血压患者左心室结构和功能的影响

目的:探讨伴或不伴高尿酸血症的高血压患者左心室结构异常及其危险因素,应用三维斑点追踪技术(Three-di-mensional speckle tracking imaging,3D-STI)评价其左心室收缩功能.方法:招募健康体检者40例(对照组),入选185例射血分数正常的原发性高血压患者(病例组),根据是否合并高...

Evaluation of the effect of hyperuricemia on left ventricular structure and function in patients with hypertension using three-dimensional speckle tracking imaging

Objective:To investigate the left ventricular structural abnormalities and their risk factors in hypertensive patients with or without hyperuricemia,and to evaluate left ventricular systolic function by three-dimensional speckle tracking technique(3 D-STI).Methods:Forty healthy persons were recruited as control group.A total of 185 patients with hypertension preserved ejection fraction,as case group,were enrolled.These patients were divided into hypertension group(147 cases)and hypertension+hyperuricemia group(38 cases)according to whether the hyperuricemia was combined or not.All subjects underwent routine and three-dimensional echocardiography testing,images were stored,and risk factors for left ventricular remodeling were analyzed using multivariable Logistic regression,global longitudinal strain(GLS),circumferential strain(GCS),area strain(GAS)and radial strain(GRS)of left ventricle which were measured by 3 D-STI.Results:There was significant difference in the ratio of left ventricular morphology in each group.Compared with the control group,there were more abnormal left ventricular configurations in the two hypertension groups,and left ventricular hypertrophy was the most sign common in hypertension+hyperuricemia group.Compared with the control group,the GLS of hypertension group decreased(P<0.05),the GLS,GAS,GCS and GRS of hypertension+hyperuricemia group decreased(P>0.05),and the GLS,GAS,GCS and GRS of hypertension+hyperuricemia group decreased(P<0.05).Compared with the hypertension group,the GLS,GAS,GCS and GRS were decreased in hypertension+hyperuricemia group(P<0.05).Conclusion:With a normal ejection fraction,conventional echocardiography combined with 3 D-STI technique can detect structural abnormalities and dysfunction of the left ventricle in hypertensive patients with or without hyperuricemia.