ATP柠檬酸裂解酶基因多态性与妊娠期糖尿病的相关性

目的 探讨ATP柠檬酸裂解酶(ACLY)基因多态性与妊娠期糖尿病(GDM)的相关性.方法 选取2017年3月至2019年5月于我院行定期产检的519例孕妇,根据国际妊娠合并糖尿病研究组织制定的GDM诊断标准,将其中诊断为GDM的264例孕妇作为GDM组,将诊断为正常的255例孕妇作为对照组.采用Sequenom飞行质谱...

Association between ATP citrate lyase gene polymorphism and gestational diabetes mellitus

Objective To investigate the association between ATP citrate lyase(ACLY)gene polymorphism and gestational diabetes mellitus(GDM).Methods A total of 519 pregnant women who underwent regular prenatal examination in our hospital from March 2017 to May 2019 were selected.According to the GDM diagnostic criteria formulated by international research organization on gestational diabetes mellitus,264 pregnant women diagnosed as GDM were selected as GDM group,and 255 pregnant women diagnosed as normal were selected as control group.The SNP genotypes were detected by sequenom flight mass spectrometry,and the correlation between SNP loci rs2304497,rs9912300 and the risk of GDM was analyzed under different genetic models.Results The GG,GT and TT genotypes of rs9912300 loci analyzed by genetic model found that the rs9912300 mutation genotype was significantly associated with the reduced risk of GDM(OR=0.59,P=0.04).There was no significant association between different genotypes of rs2304497 loci and GDM risk.Conclusion The SNP loci rs9912300 of ACLY gene is associated with the risk of GDM,which may be a predictive index of GDM risk.