128例2型糖尿病合并尿路感染的常见病原菌及相关危险因素分析

目的探讨2型糖尿病合并尿路感染患者的常见病原菌,并对耐药性及危险因素进行分析,为临床诊治提供依据。方法回顾性分析我院2009年6月至2011年12月收治的确诊为2型糖尿病合并尿路感染患者的临床资料,统计分析中段尿细菌培养加药敏试验检查结果及危险因素。结果 2型糖尿病合并尿路感染发生率为25.80%,以革兰阴性菌为主,占80.47%(103/128),常见革兰阴性杆菌对亚胺培南、哌拉西林/他唑巴坦、阿米卡星敏感性高;常见革兰阳性菌对万古霉素、吗啉恶酮/利奈唑胺敏感性高,对环丙氟哌酸、红霉素的耐药性最高。年龄较大、女性患者、血糖偏高及病程长是尿路感染的危险因素,差异有统计学意义(P<0.05)。结论年龄、性别、血糖和病程是2型糖尿病合并尿路感染的易感因素;2型糖尿病合并尿路感染耐药性高,临床应按药敏结果合理选择抗生素。

Analysis of Common Pathogens and Associated Risk Factors in 128 Cases of Type 2 Diabetes with Urinary Tract Infections

Objective To explore the common pathogens in type 2 diabetes with urinary tract infection,and provide the clinical diagnosis and treatment through analysis on the drug resistance and risk factors.Methods Clinical data of type 2 diabetes with urinary tract infection were retrospectively analyzed from June 2009 to December 2011;the middle of urine bacteria cultivation of drug sensitive experiment test results and risk factors were analyzed.Results Type 2 diabetes combined with urinary infection rate was 25.80%,mainly composed of gram-negative bacteria by 80.47%(103/128),common gram-negative bacteria were sensitive to imipenem,piperacillin/sulbactam,and amikacin;common gram-positive bacteria were sensitive to vancomycin,linezolid/rina thiazole amine,and were mostly resisted to ciprofloxacin and erethromycin.Older age,female patients,high blood sugar and the long disease coursewere urinary infection risk factors,the difference was statistically significant(P<0.05).Conclusion Age,gender,blood sugar and course of the disease are the susceptible factors of type 2 diabetes with urinary tract infection,which has high drug resistance,therefore antibiotics should be reasonably selected according to the drug sensitivity test results.