Triterpenoid saponins with anti-inflammatory activity from Codonopsis lanceolata |
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Authors: | Xu Li-Ping Wang Hao Yuan Zhong |
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Institution: | School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China. |
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Abstract: | Six triterpenoid saponins, including a new compound named codonolaside III, were isolated from the roots of Codonopsis lanceolata. The spectral and chemical data revealed the structure of codonolaside III to be 3- O- beta- D-xylopyranosyl -(1-->3)- beta- D-glucuronopyranosyl]-3 beta,16 alpha-dihydroxyolean-12-ene-28-oic acid 28- O- beta- D-xylopyranosyl-(1-->4)- alpha- L-rhamnpyranosyl-(1-->2)] beta- D-glucopyranosyl -(1-->4)]- alpha- L-arabinopyranosyl ester. The xylene-induced mouse ear edema inhibitory effect assay disclosed codonolaside and codonolasides I - III as the major anti-inflammatory constituents in this crude drug. |
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