Acoustic overstimulation alters the morphology of the tectorial membrane |
| |
Authors: | Barbara Canlon |
| |
Institution: | Physiology Department II, Karolinska Institute, Stockholm, Sweden |
| |
Abstract: | After a permanent threshold shift was induced by exposing guinea pigs to a 1 kHz pure tone at 105 dB(A) for 72 h, light microscopic observations of freshly dissected and stained tectorial membranes showed an increased waviness and clumping of the fibers of the middle zone. Hensen's stripe was not seen as a continuous dense structure running through the middle zone but was at times discontinuous and curved. As measured from cross-sections of the cochlea, the thickness of the tectorial membrane was decreased after acoustic overstimulation. The stereocilia of the inner and outer hair cells lie directly under the middle zone. Visual detection levels of threshold of tectorial membrane movement was determined by stimulating the marginal zone of the tectorial membrane of isolated cochlear coils by an oscillating water jet. After acoustic overstimulation the tectorial membrane became more compliant. The tectorial membrane abnormalities were restricted to the regions of the cochlea that demonstrated a 40–50 dB hearing loss. |
| |
Keywords: | Acoustic overstimulation Cochlea Hensen's stripe Tectorial membrane |
本文献已被 ScienceDirect 等数据库收录! |