Effects of tamoxifen on Doppler velocimetry parameters of periurethral vessels in postmenopausal women

The purpose of the present study was to assess the effect of tamoxifen on periurethral vessels by Doppler velocimetry examination. Increase in the number of these vessels as well as decrease in resistance and pulsatility indices by tamoxifen were observed.Editorial Comment: This study of the effects of a SERM on the periurethral vessels is quite timely in light of the rampant decrease in hormone therapy. We expect to see an increase in women using a SERM for the indication of osteoporosis. In future, we look forward to studies that will demonstrate a connection between the flood flow to the urethra and lower urinary tract function. This may lead to more directed topical therapies