| 过继免疫疗法对子宫内膜异位症模型鼠免疫功能的影响 |
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| 引用本文： | 李淑萍,萧美如,李同玺,陆伯刚.过继免疫疗法对子宫内膜异位症模型鼠免疫功能的影响[J].武警医学院学报,1999(3). |
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| 作者姓名： | 李淑萍 萧美如 李同玺 陆伯刚 |
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| 作者单位： | 武警医学院中医学教研室!天津，300162，天津医科大学第二附属医院妇科!天津，300162，天津中医学院第二附属医院病理科!天津，300162，天津医科大学免疫学教研室!天津，300162 |
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| 摘 要： | 目的：探讨过继免疫疗法对子宫内膜异位症的疗效及免疫功能的影响。方法：38只SD大鼠随机分为空白对照、模型对照、LAK细胞注射、LHRH－a注射四组。观察异位病灶变化，并分别测定各组大鼠腹腔液中自然杀伤细胞（NK细胞）活性及血清中白细胞介素－6（IL－6）、子宫内膜抗体（EMAb）的水平。结果：LAK细胞治疗组异位内膜萎缩，NK细胞活性提高，IL－6水平与子宫内膜抗体含量下降，各项指标与模型组均有显著差异。结论：LAK细胞能调整子宫内膜异位症紊乱的免疫机制，提示过继免疫疗法对子宫内膜异位症具有治疗作用。
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| 关 键 词： | 子宫内膜异位症 LAK细胞 过继免疫疗法 |
Effect of adoptive immunotherapy on immune disturbances of EMT rats |
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| Li Shuping,Xiao Meiru, Li Tongxi, Lu Bogang.Effect of adoptive immunotherapy on immune disturbances of EMT rats[J].Acta Academiae Medicinae CPAPF,1999(3). |
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| Authors: | Li Shuping Xiao Meiru Li Tongxi Lu Bogang |
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| Abstract: | Objective: To investigate the changes of immunobiology of endometriosis (EMT) rats after adoptive immunotherapy (AIT). Methods: 38 SD rats were divided into four groups as thenormal group, the EMT model group, the lymphokine activated killer (LAK) cells group, the LHRH-a group. The natural killer(NK) cells activity in peritioneal fluid, interleukin-6 (IL-6) ac-tivity, and endometrium antibody (EMAb) content in serum were measured. Pathological changes of endometriosis were observed. Results: LAK cells group improved significantly NK cells activity, and reduced IL-6 activity and the content of EMAb in serum. Conclusion: LAK cells could rectify the immune disturbances of EMT. It implied that AIT is a potential target for treatment in EMT. |
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| Keywords: | Endometriosis Lymphokine activated killer cells Adoptive immunotherapy |
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