Protecting effects of vasoactive intestinal polypeptide on lymphocytes against metal toxicity. |
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| Authors: | K Nordlind L Bondesson B Agerberth V Mutt |
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| Affiliation: | Department of Dermatology, Karolinska Hospital, Stockholm, Sweden. |
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| Abstract: | The hormonal neuropeptides calcitonin gene-related peptide (CGRP), cholecystokinin (CCK), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP), were investigated for a potential protective effect on thymocytes after a toxic dose of nickel sulfate, giving an inhibition of DNA synthesis. There was a statistically significant increase in the synthesis of DNA from the level caused by nickel sulfate, with VIP, 10(-4)-10(-5) mol/l, while the slightly stimulating effects obtained with CGRP, CCK and NPY, were statistically non-significant. This indicates that VIP, at least as pharmacological concentrations, might have protective effects on lymphocytes against metal toxicity. |
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