Metabolic syndrome and arterial stiffness: the Health 2000 Survey |
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Authors: | Sipilä Kalle Koivistoinen Teemu Moilanen Leena Nieminen Tuomo Reunanen Antti Jula Antti Salomaa Veikko Kaaja Risto Kööbi Tiit Kukkonen-Harjula Katriina Majahalme Silja Kähönen Mika |
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Institution: | a Department of Clinical Physiology, Medical School, University of Tampere, FI-33014 Tampere, Finland b Department of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland c Department of Medicine, Kuopio University Hospital, 70211 Kuopio, Finland d Department of Clinical Pharmacology, Medical School, University of Tampere, FI-33014 Tampere, Finland e Department of Health and Functional Capacity, National Public Health Institute, FI-00300 Helsinki, Finland f Department of Epidemiology and Health Promotion, National Public Health Institution, FI-00300 Helsinki, Finland g Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, FI-00029 Helsinki, Finland h UKK Institute for Health Promotion Research, FI-33501 Tampere, Finland i Appleton Heart Institute, Appleton, WI 54911, USA |
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Abstract: | Metabolic syndrome and its components have been associated with arterial stiffness and cardiovascular disease. The objective of this study was to examine the independent influences of metabolic syndrome, its components, and other cardiovascular risk factors on arterial stiffness as well as to compare 2 definitions for metabolic syndrome (National Cholesterol Education Program NCEP] and International Diabetes Federation IDF]) in their ability to identify subjects with arterial stiffness. The study population consisted of 401 Finnish men and women aged 45 years and older who participated in a substudy of the Finnish population-based Health 2000 Survey. Pulse wave velocity (PWV) measured by whole-body impedance cardiography was used as a marker of elevated arterial stiffness. In multivariate models, systolic blood pressure, age, waist circumference, and fasting blood glucose (P ≤ .001 for all) were independent determinants for PWV. In the models including metabolic syndrome instead of its components, the NCEP and IDF definitions were similarly associated with PWV (P ≤ .01 for both), the other independent determinants being age, sex (P < .001 for both) and plasma C-reactive protein concentration (P = .016 and P = .005 in models containing the NCEP and IDF definitions, respectively). Systolic blood pressure, age, waist circumference, and fasting blood glucose level were independently associated with increased arterial stiffness. Metabolic syndrome determined increased arterial stiffness independently of other known cardiovascular risk factors. The NCEP and IDF definitions did not differ in their ability to identify subjects with increased arterial stiffness. |
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