二氧化钛纳米管抗菌性能在口腔种植领域的研究进展

钛(Ti)及其合金已被广泛应用于口腔种植领域.但由于纯钛表面是生物惰性的,细菌易粘附于其表面并形成生物膜,这是导致种植体植入术后感染的主要原因.通过阳极氧化法可在钛表面制备出紧密排列的纳米管状结构,形成的二氧化钛纳米管(TiO2纳米管)具有高比表面积、高亲水性的特点.TiO2纳米管表面可促进成骨细胞粘附增殖并有效减少细...

Research progress in antibacteria properties of titanium dioxide nanotube used for dental implantation

Titanium(Ti)and its alloys have been widely used in dental implant.However,as the surface of pure titanium is biologically inert,bacteria tend to adhere to its surface and form biofilms,which is the main cause of infection after implant implantation The tightly arranged titanium dioxide nanotube(TiO2 nanotube)structure can be prepared using electrical anodization method.The produced nanotube has the characteristics of high specific surface area and high hydrophilicity.TiO2 nanotube surface can promote the adhesion and proliferation of osteoblasts and effectively reduce the initial colonization of bacteria,thus reducing the risk of infection after implantation.Under ultraviolet irradiation,photocatalytic reactions can produce reactive oxygen species with high oxidizability,which can destroy cell walls and membranes of bacteria.Moreover,due to it’s unique lumen structure,nanotubes can be used as drug carriers for antibacterial agents.By changing the size of nanotubes and performing biological modification on their surfaces,the drug loading performance of nanotubes can be improved and the ideal drug release can be achieved.In the present article,the research progress of the antibacterial performance of nanotubes was reviewed from three aspects including the antibacterial mechanism of pure TiO2 nanotubes structure,photocatalytic sterilization,and serving as the drug delivery carrier.