醒脑静治疗脑梗死30例疗效观察

目的:探究醒脑静治疗脑梗死的临床疗效及其作用机制。方法:选取2016年1月至2019年4月期间铅山县人民医院收治的60例脑梗死患者作为研究对象,采用随机数表法分为观察组和对照组,每组各30例,对照组采用依达拉奉治疗,观察组在对照组基础上加用醒脑静治疗,两组均治疗14d。观察记录两组患者临床疗效,血清炎性因子高敏C反应蛋白(hs-CRP)、血清肿瘤坏死因子α(TNF-α)、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)水平,血清自由基超氧化物歧化酶(SOD)、丙二醛(MDA)水平,血管内皮生长因子(VEGF)和血小板衍生内皮细胞生长因子(PD-ECGF)水平。结果:经治疗后,观察组总有效率(80.00%)高于对照组(63.33%),7d、14dNIHSS评分均低于对照组;观察组hs-CRP、TNF-α、IL-6水平均低于对照组,IL-10水平高于对照组;观察组SOD水平高于对照组,MDA水平低于对照组;观察组VEGF、PD-ECGF水平均高于对照组。以上均差异有统计学意义(P<0.05)。结论:醒脑静联合依达拉奉可通过改善患者炎症水平、减少自由基、加速血管修复、增加血管通透性治疗脑梗死,疗效显著。

Curative Effect of Xingnaojing on 30 Cases of Cerebral Infarction

Objective:To explore the clinical curative effect and action mechanism of Xingnaojing on cerebral infarction.Methods:60 patients with cerebral infarction who were admitted to the hospital from January 2016 to April 2019 were enrolled as study subjects.They were divided into observation group and control group by random number table method,30 cases in each group.The control group was given edaravone injection,while observation group was given edaravone combined with Xingnaojing injection.Both groups were treated for 14 days.The clinical curative effect,levels of serum inflammatory factors(CRP,TNF-α,IL-10,IL-6),serum free radicals(SOD,MDA),vascular endothelial growth factor(VEGF)and platelet-derived endothelial cell growth factor(PD-ECGF)in both groups were observed and recorded.Results:After treatment,the total response rate of observation group was higher than that of control group.At 7 d and 14 d after treatment,scores of observation group were lower than those of control group.After treatment,levels of hs-CRP,TNF-α,IL-6 in observation group were lower than those in control group,while IL-10 level was higher than that in control group.After treatment,SOD level in observation group was higher than that in control group,while MDA level was lower than that in control group.After treatment,levels of VEGF and PD-ECGF in observation group were higher than those in control group.The above differences were statistically significant(P<0.05).Conclusion:The curative effect of Xingnaojing is significant on cerebral infarction.The cerebral infarctioncan be treated by improvinginflammationlevel,reducing free radicals,accelerating vascular repai,r and increasing vascular permeability.