盐酸替罗非班联合药物洗脱支架治疗老年AMI患者的效果

目的探讨盐酸替罗非班联合药物洗脱支架治疗老年急性心肌梗死(AMI)患者的疗效及对血清肌钙蛋白(cTnI)、D-二聚体(D-D)、尿酸(UA)、肌酸激酶同工酶(CK-MB)的影响。方法选取医院收治的107例老年AMI患者,根据简单随机分组法将其分为两组,对照组(n=53)采用药物洗脱支架治疗,观察组(n=54)予以盐酸替罗非班联合药物洗脱支架治疗,对比两组治疗效果、血清c TnI、D-D、UA、CK-MB水平以及心脏不良事件。结果观察组临床疗效总有效率高于对照组,差异有统计学意义(P<0.05)。观察组治疗后TIMI血流分级优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血清cTnI、D-D、UA、CK-MB水平均低于对照组,观察组治疗前后各指标差值均大于对照组,差异有统计学意义(P<0.05)。观察组主要不良心血管事件(MACE)发生率低于对照组,差异有统计学意义(P<0.05)。结论盐酸替罗非班联合药物洗脱支架治疗老年AMI患者疗效显著,能够有效降低血清c TnI、D-D、UA、CK-MB水平,减少心脏不良事件发生。

Effects of tirofiban hydrochloride combined with drug eluting stent in the treatment of el⁃derly patients with AMI

Objective To explore the curative effect of tirofiban hydrochloride combined with drug eluting stent(DES)on elderly patients with acute myocardial infarction(AMI)and its influences on se?rum cardiac troponin I(cTnI),D?dimer(D?D),uric acid(UA)and creatine kinase isoenzyme(CK?MB).Methods A total of 107 elderly AMI patients who were admitted to the hospital were enrolled and divided in?to the control group(n=53,DES)and the observation group(n=54,tirofiban hydrochloride combined with DES)by the simple random grouping method.Curative effect,levels of serum cTnI,D?D,UA and CK?MB,and adverse cardiac events were compared between the two groups.Results The total response rate of clinical curative effect in the observation group was higher than that in the control group,and the difference was statis?tically significant(P<0.05).After treatment,the blood flow classification of TIMI in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).After treat?ment,the levels of serum cTnI,D?D,UA and CK?MB in the observation group were lower than those in the control group,the difference value of each indicator before and after treatment in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).The incidence of major adverse cardiovascular event(MACE)was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Tirofiban hydrochloride combined with a drug?eluting stent has a significant effect in the treatment of elderly patients with AMI.It can effectively reduce serum cTnI,D?D,UA,CK?MB levels and reduce the occurrence of adverse cardiac events.