A retrospective evaluation of causes of exempting living liver donors in an Egyptian centre |
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| Authors: | Hisham Aboueisha Tamer Elbaz Karim Hosny Ahmed Bravo Mostafa Elshazli Ayman Salah Ezz Korashi Adel Hosny |
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| Affiliation: | 1. General Surgery Department, Kasr El-Aini Faculty of Medicine, Cairo University, Cairo, Egypt;2. Tropical Medicine and Hepatology Department, Kasr El-Aini Faculty of Medicine, Cairo University, Cairo, Egypt;1. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, United States;2. Center for Comprehensive Informatics, Emory University, Atlanta, GA, United States;3. Department of Pediatrics, Emory University School of Medicine and Children''s Hospital of Atlanta, Atlanta, GA, United States;4. Department of Radiology, Emory University School of Medicine, Atlanta, GA, United States;5. Department of Radiology, University of Arizona College of Medicine, Tucson, AZ, United States;2. Pathology;4. Gastroenterology and;3. Corporación del Trasplante, Santiago, Chile;1. Department of General, Visceral and Transplant Surgery, Uniklinik RWTH Aachen, Aachen, Germany;2. Department of Internal Medicine, Uniklinik RWTH Aachen, Aachen, Germany;3. Department of Anaesthesiology, Uniklinik RWTH Aachen, Aachen, Germany;4. Department of General and Visceral Surgery, Sana Hospital Düsseldorf-Gerresheim, Germany;1. Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea;2. Multi-organ Abdominal Transplant, King Fahad Specialist Hospital, Saudi Arabia;3. Division of Transplantation, University of Minnesota;4. Division of Liver/GI Transplant, Miami Transplant Institute, University of Miami Miller School of Medicine;1. Department of Ultrasound, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, China;2. GuangDong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, China;3. Department of Radiology, Mayo Clinic, Rochester, MN, USA;4. Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital; Organ Transplantation Institute, Sun Yat-Sen University; Organ Transplantation Research Center of Guangdong Province; Guangdong Province Engineering Laboratory for Transplantation Medicine, 600 Tianhe Road, Guangzhou, China;5. Department of Pathology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, China |
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| Abstract: | Background and study aimsLiving-related liver transplantation has helped to solve the problem of shortage of deceased organ donors. However, studies showed significant donor complications occurring with adult living liver donation. This study aims at assessing different causes of exclusion of potent living donor transplantation in Egypt.Patients and methodsThe data of 158 living donors (corresponding to 50 consecutive transplanted cases) were retrospectively studied.ResultsOnly 50 donors were found to meet all the preoperative assessment criteria while 108 potential donors were excluded at various assessment steps. Majority of the excluded potential donors were due to anatomical variations (52/108) followed by hepatic steatosis (19/108) and positive hepatitis B or C virus serology (11/108). Regarding the anatomic variations, biliary anomalies were ranked as the first cause to exclude donors with the majority of them having the type C biliary variant. Portal vein variations were the second most common cause of exclusion due to portal vein trifurcation. Hepatic artery variations were detected in a lesser number of excluded donors. No donors were excluded for hepatic vein anomalies.ConclusionAnatomical variations are the most common causes to exempt living liver donors. Preoperative evaluation of anatomical variations, viral serology and hepatic steatosis plays the major role to accept or exclude the potential donors. |
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