血清IGF-1含量对STEMI患者急诊介入术后MACE的预测价值

目的研究血清胰岛素样生长因子-1(IGF-1)含量对ST段抬高型心肌梗死(STEMI)患者急诊介入术后主要不良心血管事件(MACE)的预测价值。方法选择2017年6月至2020年6月期间在本院接受急诊介入手术的STEMI患者作为STEMI组、同期体检的健康志愿者作为对照组,检测血清IGF-1的含量。随访STEMI患者介入术后6个月内发生MACE的情况,采用ROC曲线分析IGF-1对MACE的预测价值、采用Logistic回归分析MACE的影响因素。结果与对照组比较,STEMI组患者血清中IGF-1的含量明显降低,差异有统计学意义(P<0.05);ROC曲线分析显示,IGF-1预测MACE的曲线下面积为、最佳截断值为87.64 ng/mL;STEMI组中MACE患者的血清IGF-1含量明显低于非MACE患者,MACE患者的hs-CRP含量、cTnI峰值、Gensini评分、多支病变比例明显高于非MACE患者,差异有统计学意义(P<0.05);logistics回归分析显示,IGF-1含量、cTnI峰值、Gensini评分是STEMI患者发生MACE的影响因素。结论 STEMI患者血清IGF-1含量明显降低,IGF-1含量对介入术后6个月内发生MACE具有预测价值。

Predictive value of serum IGF?1 contents on major adverse cardiovascular events after emergency intervention in STEMI patients

Objective To study the predictive value of serum insulin?like growth factor?1(IGF?1)on major adverse cardiovascular events(MACE)of patients with ST segment elevation myocardial infarc?tion(STEMI)after emergency intervention.Methods STEMI patients who underwent emergency interven?tion in our hospital from June 2018 to June 2019 were selected as the STEMI group and healthy volunteers who had physical examination at the same time as the control group,then serum IGF?1 level was detected.The MACE of STEMI patients within 6 months after intervention was followed up.ROC curve was used to analyze the predictive value of IGF?1 on MACE,and logistic regression was used to analyze the influencing factors of MACE.Result Compared with the control group,the serum IGF?1 level in the STEMI group was significant?ly lower,the difference was statistically significant(P<0.05);ROC curve analysis showed that the area under curve of IGF?1 in predicting MACE was,and the best cutoff value was 87.64 ng/mL.The serum IGF?1 level of MACE patients in the STEMI group was significantly lower than that of non MACE patients,and the hs?CRP content,cTnI peak value,Gensini score and the proportion of multi vessel lesions of MACE patients were significantly higher than those of non MACE patient,the difference was statistically significant(P<0.05).Logis?tic regression analysis showed that IGF?1,cTnI peak value and Gensini score were the influencing factors of MACE in STEMI patients.Conclusion The level of serum IGF?1 in patients with STEMI is significantly re?duced,and the level of IGF?1 has predictive value for MACE within 6 months after intervention.