Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity |
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| Authors: | Parvaneh Pakravan Soheila Kashanian Mohammad M Khodaei Frances J Harding |
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| Institution: | 1. Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, I.R. Iran;2. Department of Chemistry, Sensor and Biosensor Research Center (SBRC) & Nanoscience and Nanotechnology Research Center (NNRC), Faculty of Science, Razi University, Kermanshah, I.R. Iran;3. Mawson Institute, University of South Australia, Adelaide, South Australia 5001, Australia |
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| Abstract: | Isatin, 1H-indole-2,3-dione, is a heterocyclic compound of significant importance in medicinal chemistry. It is a synthetically versatile molecule, a precursor for a large number of pharmacologically active compounds. Isatin and its derivatives have aroused great attention in recent years due to their wide variety of biological activities, relevant to application as insecticides and fungicides and in a broad range of drug therapies, including anticancer drugs, antibiotics and antidepressants. The purpose of this review is to provide an overview of the pharmacological activities of isatin and its synthetic and natural derivatives. Molecular modifications to tailor the properties of isatin and its derivatives are also discussed. |
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| Keywords: | isatin derivatives DNA and HSA binding antimicrobial anticancer anticonvulsant antioxidant |
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