Lung Transplantation in Children. Specific Aspects |
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Authors: | Antonio Moreno Galdó Juan Solé Montserrat Antonio Roman Broto |
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Affiliation: | 1. Department of Medicine, Institute of Clinical Medicine, University of Eastern Finland and Department of Medicine, Kuopio University Hospital, Kuopio, Finland;2. EBMT Lymphoma Working Party, Barcelona, Spain;3. Department of Hematology, Hopital de Purpan, CHU, Toulouse, France;4. Department of Hematology, University College London Hospital, London, UK;5. Department of Hematology, Hopital Haut-Leveque, CHU Bordeaux, Pessac, France;6. Department of Hematology, Hopital Necker, Paris, France;7. Department of Hematology, Cliniques Universitaires St Luc, Brussels, Belgium;8. Department of Hematology, Centre Leon Bernard, Lyon, France;9. Department of Hematology, Addenbrookes Hospital, Cambridge, UK;10. Department of Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;11. EBMT Data Office, Faculté de Médecine Saint-Antoine, Paris, France;12. Department of Hematology, Centre Henri Becquerel, Rouen, France;13. Department of Hematology, Hotel Dieu, Paris, France;14. Department of Hematology, Hague Hospital, The Hague, The Netherlands;15. Department of Medicine V, University of Heidelberg, Heidelberg, Germany;16. Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain |
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Abstract: | Lung transplantation has become in recent years a therapeutic option for infants with terminal lung disease with similar results to transplantation in adults. In Spain, since 1996 114 children lung transplants have been performed; this corresponds to 3.9% of the total transplant number. The most common indication in children is cystic fibrosis, which represents between 70-80% of the transplants performed in adolescents. In infants common indications are interstitial lung disease and pulmonary hypertension. In most children a sequential double lung transplant is performed, generally with the help of extracorpo-real circulation. Lung transplantation in children presents special challenges in monitoring and follow-up, especially in infants, given the difficulty in assessing lung function and performing transbronchial biopsies.There are some more specific complications in children like postransplant lymphoproliferative syndrome or a greater severity of respiratory virus infections. After lung transplantation children usually experiment a very important improvement in their quality of life. Eighty eight per cent of children have no limitations in their activity after 3 years of transplantation. According to the registry of the International Society for Heart & Lung Transplantation (ISHLT) survival at 5 years of transplantation is 54% and at 10 years is around 35%. |
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Keywords: | Lung transplant Children Cystic fibrosis Pulmonary hypertension Pulmonary hypertension Trasplante pulmonar Niños Fibrosis quística Hipertensión pulmonar Neumopatías intersticiales |
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