Prevalence of Anaemia Associated With Chronic Obstructive Pulmonary Disease. Study of Associated Variables |
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| Authors: | Lorena Comeche Casanova Jose María Echave-Sustaeta Ricardo García Luján Irene Albarrán Lozano Pablo Alonso González María Jesús Llorente Alonso |
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| Affiliation: | 1. Servicio de Neumología, Hospital Universitario Quirón Madrid, Universidad Europea de Madrid, Madrid, Spain;2. Departamento de Estadística, Universidad Carlos III, Madrid, Spain;3. Departamento de Estadística, Estructura Económica y Organización Económica Internacional, Universidad de Alcalá de Henares, Alcalá de Henares, Madrid, Spain;4. Servicio de Bioquímica, Hospital Universitario de Móstoles, Móstoles, Madrid, Spain;1. Hospital Cayetano Heredia, Peru;2. Instituto de Investigaciones de la Altura, Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Peru;1. Department of Applied Chemistry, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh 202 002, India;2. Department of Textile Engineering, Konkuk University, Seoul 143-701, Republic of Korea;3. Center for Material Architecting, Korea Institute of Science and Technology (KIST), Seoul 136-791, Korea;1. Ph.D. Student (Economics and Management Program), Universidad de Alcalá, Spain;2. Economics Department, Universidad de Alcalá, Plaza de la Victoria 2, 28802 Alcalá de Henares, Spain;1. Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;2. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;3. Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA;4. Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA;5. Department of Epidemiology, Harvard School of Public Health, Boston, MA |
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| Abstract: | BackgroundAnaemia is one of the extrapulmonary manifestations of chronic obstructive pulmonary disease (COPD). Its real prevalence, physiopathology and clinical repercussion are unknown. The objectives of our study were: to determine the prevalence of anaemia in patients with stable COPD not attributable to other causes and to establish the relationship of anaemia with clinical, prognostic and inflammatory markers with an important role in COPD.MethodsThe study included stable COPD patients with no other known causes of anaemia. The following tests were carried out: respiratory function tests; serum determination of erythropoietin and inflammatory markers: high sensitivity C-reactive protein (hs-CRP), fibrinogen, interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor α (TNF-α). Body mass index (BMI), Charlson and BODE indices, the number of exacerbations in the previous year, dyspnoea and quality of life were also calculated.ResultsOne hundred and thirty patients were included. Anaemia prevalence was 6.2%. Mean haemoglobin value in anaemic patients was 11.9 ± 0.95 g/dL. Patients with anaemia had a lower BMI (P=.03), higher Charlson index (P=.002), more elevated erythropoietin levels (P=.016), a tendency to present a lower FEV1% value (P=.08) and significantly lower IL-6 values when compared to non-anaemic patients (P=.003).ConclusionsIn our series, the anaemia associated with COPD was less prevalent than that published in the literature to date, and was related to certain clinical and inflammatory markers. |
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| Keywords: | Anaemia Chronic obstructive pulmonary disease Prevalence Interleukin Erythropoietin Anemia Enfermedad pulmonar obstructiva crónica Prevalencia Interleucinas Eritropoyetina |
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