HCV、HBV与肝硬变及原发性肝癌关系的初步探讨

作者对８０例肝硬变（ＬＣ）、１１２例原发性肝癌（ＰＨＣ）的血清抗ＨＣＶ及ＨＢＶ检测发现：（１）ＰＨＣ、ＬＣ的抗ＨＣＶ阳性率分别为２８．６％和１８．８％，ＨＢＶ阳性率分别为６４．３％和６７．５％；（２）有无用血液及血液制品者间的抗ＨＣＶ及ＨＢＶ阳性率差异显著；（３）ＬＣ、ＰＨＣ患者的抗ＨＣＶ阳性率在ＨＢＶ阴性（１５．４％和２５％）与ＨＢＶ阳性（２０．４％和３０．６％）间无明显差异；（４）在抗ＨＣＶ阴、阳性ＰＨｃ中，抗ＨＢｅ、抗ＨＢｃ单阳性率，抗ＨＢｓ与抗ＨＢＣ及抗ＨＢｃ与抗ＨＢｅ双阳性率，差异非常显著。结果表明，ＨＢＶ感染仍为ＬＣ及ＰＨＣ的主要致病因素，但ＨＣＶ与ＨＢＶ存在着重叠感染，亦可能起着共同作用。

THE CORRELATION OF HEPATITIS C,HEPATITIS B AND LIVER CIRRHOSIS WITH PRIMARY HEPATOCARCINOMA

Serum anti-HCV and HBV were assessed in 80 liver cirrhosis(LC)and 112 primary hepatocarcinoma(PHC) patients. The results showed that(1)18.8%LC and 28.6 % PHC patients were anti-HCV positive,and 67.5 % LC and 64.3 % PHCpatients were anti-HBV positive.(2)the positive rates of anti-HCV and HBV in LC andPHC patients after blood and/or blood product transfusion(BT)were statistically higherthan those of LC and PHC patients without BT.(3)the prevalence of anti- HCV in HBV-positive and negative LC(20.4 % and 15.4%)and PHC(30.6%and 25%)patients werenot significantly different.(4)the positive rates of anti-HBc,anti-HBe,both anti-HBcand anti-HBs,and anti-HBs combined anti-HBc in anti-HCV positive and negativePHC patients were significantly different.Perhaps these data suggested that HBV is anmore important factor associated with LC and PHC. However,the combined infectionwith HCV and HBV may play an coorperation role in the pathogenesis of LC and PHC.