| 造血干细胞移植供受者HLA-C分子结构分析 |
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| 引用本文： | 潘兴华,王春燕,段连宁,郭坤元.造血干细胞移植供受者HLA-C分子结构分析[J].热带医学杂志,2002,2(2):139-142. |
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| 作者姓名： | 潘兴华 王春燕 段连宁 郭坤元 |
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| 作者单位： | 1. 第一军医大学附属珠江医院血液科,广州,510282
2. 中山大学中山医学院病理生理教研室,广州,510080 |
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| 摘 要： | 目的 观察造血干细胞移植（HSCT）供受HLA－C分子结构差异，探讨免疫抑制信号系统在HSCT后GVHD的中作用。方法 利用DNA测序和蛋白质三维空间结构模拟分析方法回顾性观察HSCT后发生GVHD的供受的HLA－C分子结构差异。结果 HLA－C分子在氨基酸序列、三维空间结构、电性分布和分子表面结构上有明显差异。结论 HSCT供受间HLA－C分子结构差异导致HLA－C分子不能被供免疫细胞的杀伤细胞抑制性受体识别，从而促进了GVHD的发生。
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| 关 键 词： | HLA－C分子 造血干细胞移植 GVHD 分子结构 移植物抗宿主病 免疫抑制 |
| 文章编号： | 0254-900X(2002)02-0139-04 |
| 修稿时间： | 2002年5月3日 |
Analyzing HLA-C Structure Between Donors and Recipient After Hematopoietic Stem Cell Transplantation |
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| Pan Xinghua,Wang Chunyan,Duan Lianning,Guo Kunyuan The.Analyzing HLA-C Structure Between Donors and Recipient After Hematopoietic Stem Cell Transplantation[J].Journal Of Tropical Medicine,2002,2(2):139-142. |
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| Authors: | Pan Xinghua Wang Chunyan Duan Lianning Guo Kunyuan The |
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| Institution: | Pan Xinghua,Wang Chunyan,Duan Lianning,Guo Kunyuan The Department of Hematology,the Zhujiang Hospital of the First Military University,Guangzhou 510282 |
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| Abstract: | Objective To compare the difference of HLA C structures between donor and recipient after hematopoietic stem cell transplantation(HSCT),we investigated the impact of immunization inhibitory signals on graft versus host disease(GVHD)after HSCT.Method The difference of HLA C structures in a pair of donors and recipient in HSCT therapy with GVHD by detecting DNA sequecing and analyzing the domain structure of protein.Result There are obviously difference of HLA C structures between donors and recipients in amino acid sequences,three dimensional structures,electronic power and surface configuration.Conclusion The difference of HLA C structures between donors and recipients in HSCT resulted that HLA C of recipients cannot be identified by killer cell inhibitory receptor of donors,this may cause GVHD. |
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| Keywords: | HLA C HSCT molecular structure GVHD |
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