Dysfunction and correction of microsomal enzyme oxidation, glucuronidation and glutathione conjugation of xenobiotics in the liver of deoxycholate-intoxicated rats |
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| Authors: | M. I. Bushma L. F. Legon'kova I. V. Zverinskii A. V. Vasil'ev |
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| Affiliation: | (1) Laboratory of Biochemical Pharmacology, Institute of Biochemistry, Belorussian National Academy of Sciences, Russia;(2) Republican Hepatological Centre, Belorussian Ministry of Health, Grodno |
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| Abstract: | Intoxication with deoxycholic acid is accompanied by destruction of hepatocyte plasma membrane (increased serum alanine aminotransferase activity) and inhibition of monooxygenase, glucuronidase and glutathione systems of rat liver. Heptral and cordiamine (mitethamide) had no effect on membrane integrity, while α-tocopherol and ursofalk (ursodeoxycholic acid) protected membranes. Ursofalk and cordiamine are superior a α-tocopherol and heptral by their ability to activity of monooxygenase, glucuronidase, and glutathione conjugating systems in the liver. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 1, pp. 56–60, January 2000 |
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| Keywords: | liver damage by deoxycholic acid biotransformation of xenobiotics heptral cordiamine ursofalk α -tocopherol |
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