114例白塞综合征的临床资料回顾性分析

目的：探讨白塞综合征的临床特点、实验室检查以及药物治疗,提高对该病的认识,更好的为临床诊疗工作提供参考,从而更加有效的进行对此病的治疗。方法：收集了新疆医科大学第一附属医院2009年1月~2013年6月期间就诊于口腔颌面外科、风湿免疫科及皮肤科病房诊治的白塞综合征患者。对发病年龄、性别、临床表现、实验室检查、治疗方案及疗效等项目列表登记,应用统计学方法得出相关结论。结果：本组资料患者共114例,男性52例（45.61%）,女性62例（54.39%）,各年龄段均可发病,发病年龄不存在性别差异（P〉0.05）。症状按发生频率由高到低排列为：口腔溃疡114例（100%）,皮肤损害76例（66.67%）,生殖器溃疡20例（17.54%）,发热25例（21.93%）,统计分析后均不存在性别差异（P〉0.05）。汉族与维吾尔族的发病类型存在差异（P〈0.05）;针刺反应阳性51例（44.74%）,统计分析后存在性别差异（P〈0.05）。常规实验室检查异常指标中：白细胞计数增加、红细胞沉降率增快存在明显性别差异。沙利度胺联合泼尼松治与免疫抑制剂联合泼尼松治疗白塞综合征效果明显优越与单一使用泼尼松。结论：白塞综合征各年龄均可发病,临床表现多样,针刺反应阳性存在显著性别性差异,民族之间不同类型存在差异,联合用药治疗效果明显优于单一用药。

Retrospective Analysis of 114 Cases of the Clinical Data of Behcet Syndrome

Objective：To analyze the clinical characteristics of Behcet syndrome,improve the understanding,and be more effective for the treatment of,and reduce the risk of recurrence. Methods： Collected the first affiliated hospital of xinjiang medical university from January 2009 to June 2013 during visits in oral and maxillofacial surgery,and dermatology wards rheumatism department lead of the diagnosis and treatment of BS. Statistical analysis of the age of onset,clinical manifestation,the incidence of auxiliary examination different sexes,drug therapy. Results：there were male patients 52 cases（45.61%）,female patients with 62 cases（54.39%）,each age all can come on,30 to 40 years old give priority to 43 patients（37.72%）. Come on gender differences in age（P＆gt;0.05）. According to the first signs the frequency from high to low arrangement for： oral ulcer 114 cases（%）,skin lesions 76 cases（66.67%）,genital ulcers 20 cases（17.54%）,fever 25 patients（21.93%）,the statistical analysis of the gender differences are not exist（P＆gt;0.05）. The Chinese and uighurs in the pathogenesis of existing types difference（P＆lt;0.05）;Acupuncture reaction positive 51 cases（44.74%）,the statistical analysis of the gender difference（P＆lt;0.05）. Routine laboratory examination of abnormal indicators are：increased WBC count,red blood cell sedimentation rate increase quickly obvious gender differences. Sally degrees amine combination treatment with prednisone is not completely type and PPD（＋） Behcet syndrome is significantly better and a single use effect prednisone. Prednisone joint immunosuppressant therapy efficacy is obvious is superior to use a single treatment with prednisone. Conclusion：BS all age all can come on,clinical manifestations of diversity,also involved much system,acupuncture positive reaction there exist significant,ethnic differences between different types,combination therapy effect is obviously superior to a single drug use.