阿托品联合长托宁治疗急性有机磷农药中毒的回顾性分析简

目的回顾性分析阿托品联合长托宁治疗急性有机磷农药中毒（acuteorganophosphoruspesticidepoison—ing，AOPP）的临床疗效。方法127例AOPP患者随机分为阿托品治疗组（Ⅰ组）、长托宁治疗组（Ⅰ组）、阿托品联合长托宁治疗组（Ⅲ组），比较三组疗效及副作用。结果①与Ⅰ、Ⅱ组比较，Ⅲ组中毒症状消失时间、全血胆碱脂酶（eholin—esterase，CHE）恢复时间、治愈时间明显缩短，至治愈用药次数减少，治愈率提高，病死率下降，且与Ⅰ组比较存在统计学差异（P〈0．05或0．01）。②Ⅲ组用药后1天及以后各时间点CHE值均明显高于其余2组，与Ⅰ组比较有统计学差异（P〈0．05或0．01）。③Ⅰ组心动过速发生率显著高于其他2组（P〈0．01）。结论阿托品联用长托宁是抢救AOPP的一种更符合临床实际的用药方式。

Retrospective Analysis of Atropine and Penehyclidine Hydrochloride in Treatment of Patients with Acute Organophosphorus Pesticide Poisoning

Objective To study the clincial efficacy of Atropine and Penehyclidine Hydrochloride in the treatment of acute organophosphorus pesticide poisoning （AOPP）. Methods A total of 127 patients with AOPP were enrolled and di- vided into Atropine group （group Ⅰ ）, Penehyclidine Hydrochloride group （group Ⅱ ）, Penehyclidine Hydrochloride and atropine group （group Ⅲ）. The variations of efficacy and side effects in three groups were measured and analyzed. Results Compared with groups Ⅰ and Ⅱ , group Ⅲ＇s poisoning symptoms disappearing time, the CHE recovery time, the cure time and the number of drugs were obviously reduced, the cure rate was improved and were significantly different between group Ⅰand Ⅲ （P（0. 05 or 0. 01）. The degree of cholinesterase （CHE） after administration of ld in group Ⅲ was obviously higher than that in the other groups, and significantly different between group Ⅰ andⅢ （P〈0. 05 or 0. 01）. ③The incidences of taehycardia was obviously increased in group Ⅰ than that in the other groups （P〈0. 01）. Conclusion Atropine and Penehyclidine Hydrochloride is effective in the treatment of AOPP.