| Twist蛋白在非小细胞肺癌中的表达及临床意义 |
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| 引用本文： | 舒红,张洪兰,赵晓东,姜卫国. Twist蛋白在非小细胞肺癌中的表达及临床意义[J]. 中国医科大学学报, 2010, 39(2): 146-149 |
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| 作者姓名： | 舒红 张洪兰 赵晓东 姜卫国 |
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| 作者单位： | 中国医科大学,附属盛京医院病理科,沈阳,110004 |
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| 摘 要： | 目的探讨扭曲蛋白(Twist protein)在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法采用S-P免疫组化法检测61例有完整资料的NSCLC术后标本中Twist蛋白的表达情况。结果Twist蛋白在NSCLC组织中的阳性表达率明显高于正常肺组织;Twist蛋白的阳性表达与肿瘤组织类型、临床分期和淋巴结转移有关;对随访超过4年的48例患者的研究发现,生存时间<4年患者的Twist蛋白表达水平较高;术后死亡影响因子的Cox风险比例模型显示,吸烟及淋巴结转移对患者术后死亡率有显著影响。结论twist基因在NSCLC的发生发展中起一定的作用,并与患者的预后有一定关系。
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| 关 键 词： | 非小细胞肺癌 扭曲蛋白 免疫组化 预后 |
Expression and Clinical Significance of Twist Protein in Non-small Cell Lung Carcinoma |
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| SHU Hong , ZHANG Hong-lan , ZHAO Xiao-dong , JIANG Wei-guo. Expression and Clinical Significance of Twist Protein in Non-small Cell Lung Carcinoma[J]. Journal of China Medical University, 2010, 39(2): 146-149 |
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| Authors: | SHU Hong ZHANG Hong-lan ZHAO Xiao-dong JIANG Wei-guo |
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| Affiliation: | SHU Hong,ZHANG Hong-lan,ZHAO Xiao-dong,JIANG Wei-guo(Department of Pathology,Shengjing Hospital,China Medical University,Shenyang 110004,China) |
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| Abstract: | Objective To study the clinical significance and the expression of Twist protein in non-small cell lung cancer(NSCLC).Methods The expression of Twist protein was examined in formalin-fixed paraffin-embedded tissue samples of 61 NSCLC by S-P immunohistochemical method.Results The expression level of Twist in NSCLC was significantly higher than that of normal lung tissue;the positive expression of Twist protein was related to the histotype,clinical stage and lymph node metastasis;the expression level of Twist... |
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| Keywords: | non-small cell lung cancer Twist protein immunohistochemistry prognosis |
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