| 肾脏病患者抗心磷脂抗体检测的临床意义 |
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| 引用本文： | 钟清,杜晓刚,陈恩静,谯林,刘渝梅. 肾脏病患者抗心磷脂抗体检测的临床意义[J]. 广东医学, 2002, 23(12): 1250-1251 |
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| 作者姓名： | 钟清 杜晓刚 陈恩静 谯林 刘渝梅 |
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| 作者单位： | 重庆医科大学附属第一医院肾内科,重庆,400016 |
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| 摘 要： | 目的探讨肾脏病患者血清中抗心磷脂抗体(anticardiolipin antibodies,ACA) 变化及意义。方法 应用酶联免疫吸附实验(ELISA)检测130例肾小球疾病患者和28例健康对照组血清中ACA水平。结果 与正常对照组比较,肾功能正常的不同类型肾脏病患者血中ACA水平增高且阳性率增加(P<0.01),慢性肾功能不全组血中ACA水平及阳性率增加差异无显著性(P>0.05);除肾病综合征外,狼疮性肾炎组ACA水平及阳性率显著高于其余各肾脏病组(P<0.05)。结论在所研究的肾脏病中血清ACA水平及其阳性率明显增加,可能与肾脏疾病高凝状态的发生有关。
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| 关 键 词： | 肾脏病 抗心磷脂抗体 高凝状态 ACA 酶联免疫吸附试验 |
| 修稿时间： | 2002-05-10 |
Significance of anticardiolipin antibodies in patients with renal diseases |
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| Zhong Qing,Du Xiaogang,Chen Enjing,et al.. Significance of anticardiolipin antibodies in patients with renal diseases[J]. Guangdong Medical Journal, 2002, 23(12): 1250-1251 |
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| Authors: | Zhong Qing Du Xiaogang Chen Enjing et al. |
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| Affiliation: | Zhong Qing,Du Xiaogang,Chen Enjing,et al. Department of the Renal Medicine,First Affiliated Hospital of Chongqing University of Medical Science,Chongqing 400016 |
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| Abstract: | Objective To investigate the significance of serum anticardiolipin antibodies(ACA) in patients with renal diseases. Methods The levels of serum ACA of 130 patients with renal diseases and 20 control subjects were measured by ELJSA. Results Compared with the control group, the levels of serum ACA and positive rate significantly increased in all kinds of renal diseases with normal renal funcn'on(P<0.01) , but there was no significant difference in the level of serum ACA and positive rate between patients with chronic renal failure and control subjects( P > 0.05) . Except for nephrotic syndrome, the levels of serum ACA and positive rate were higher in patients with lupus nephritis than those in patients with other renal diseases( P < 0.05) . Conclusion Elevated level of serum ACA may result in hypercoagulation state and may aggravate renal injury. |
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| Keywords: | Renal disease Anticardiolipin antibodies Hypercoagulable state |
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