Smac/DIABLO在上皮性卵巢癌组织中的表达及临床意义

目的：探讨Smac/DIABLO在上皮性卵巢癌组织中的表达及临床意义。方法：采用免疫组化技术分别检测30例正常卵巢、30例良性上皮性卵巢肿瘤、30例交界性上皮性卵巢肿瘤及60例上皮性卵巢癌的组织中Smac/DIABLO蛋白的表达水平。结果：在上皮性卵巢癌中Smac/DIABLO阳性表达率为41.67%（25/60）,低于良性上皮性卵巢肿瘤（83.33%,25/30）和正常卵巢组织（90.00%,27/30）,差异有统计学意义（χ2=14.06,P〈0.0083;χ2=19.15,P〈0.0083）。且随组织学分级和临床分期增高,卵巢癌组织中Smac/DIABLO表达逐渐降低（F=7.23,P〈0.05;F=4.48,P〈0.05）。Smac/DIABLO阴性表达者生存期短于阳性表达者。结论：Smac/DIABLO在上皮性卵巢癌组织中阴性表达与上皮性卵巢癌不良预后相关。

Expression of Smac/DIABLO in Epithelial Ovarian Carcinoma and Its Clinical Significance

Objective：To investigate the expression of Smac/DIABLO in epithelial ovarian carcinomas and its clinical significance.Methods：The expression of Smac/DIABLO proteins was detected with immunohistochemistry.Results：The positive expression rate of Smac/DIABLO in ovarian carcinomas was significantly lower than that in benign ovarian tumors and normal ovaries（χ2=14.06,P 0.008 3;χ2=19.15,P 0.008 3）.In ovarian carcinomas,the expression of Smac/DIABLO was significantly decreased during progression from early to advanced tumour clinical stages and histological grade（F=7.23,P 0.05;F=4.48,P 0.05）.There was relationship between the low expression of Smac/DIABLO and poor prognosis of epithelial ovarian carcinomas.Conclusions：There was low expression of Smac/DIABLO in epithelial ovarian carcinomas,Smac/DIABLO was related to the poor prognosis of ovarian carcinomas.