| MMP-9及TIMP-1在大鼠感染性脑水肿的表达及意义 |
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| 引用本文： | 田培超,王怀立. MMP-9及TIMP-1在大鼠感染性脑水肿的表达及意义[J]. 中国实用神经疾病杂志, 2007, 10(2): 9-11 |
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| 作者姓名： | 田培超 王怀立 |
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| 作者单位： | 郑州大学第一附属医院儿科,郑州,450052;郑州大学第一附属医院儿科,郑州,450052 |
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| 摘 要： | 目的探讨MMP-9及TIMP-1在大鼠感染性脑水肿的表达及意义。方法应用免疫组织化学方法（SP法）检测大鼠急性感染性脑水肿模型中MMP-9及TIMP-1的表达情况及其比值变化。结果MMP-9及TIMP-1在LPS组各时间点表达均高于对照纽且各时间点MMP-9／TIMP-1比值均明显升高（P〈0．05）。结论MMP-9及TIMP-1可能参与了感染性脑水肿的发生和发展。
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| 关 键 词： | 基质金属蛋白酶9 组织型基质金属蛋白酶抑制因子1 感染性脑水肿 |
| 文章编号： | 1673-5110（2007）02-0009-03 |
| 收稿时间： | 2006-12-25 |
| 修稿时间： | 2006-12-25 |
Expression and significance of MMP-9 and TIMP-1 in infectious brain edema of rats |
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| Tian Peichao,Wang Huaili. Expression and significance of MMP-9 and TIMP-1 in infectious brain edema of rats[J]. Chinese Journal of Practical Neruous Diseases, 2007, 10(2): 9-11 |
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| Authors: | Tian Peichao Wang Huaili |
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| Abstract: | Objective To explore the expression and significance of MMP-9 and TIMP-1 in infectious brain edema of rats. Methods The expression of MMP-9 and TIMP-1 of tissue samples of acute infectious brain edema of rats were examined by immunohistochemical technique and the ratio of MMP-9 and TIMP-1 were analyzed; meanwhile the BWC of each group were recorded also. Results The expression level of MMP-9 and TIMP-1 of LPS group were all higher than the control group. As well as the ratio of MMP-9 and TIMP-1 was significant higher. Conclusion Both MMP-9 and TIMP-1 might play roles in forming and developing infectious brain edema of rats. |
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| Keywords: | Matrix metalloproteinase-9 Tissue inhibitor of metalloproteinase-1 Infectious brain edema |
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