| 日本血吸虫可溶性虫卵抗原致敏对树突状细胞功能的影响 |
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| 引用本文： | 段新文. 日本血吸虫可溶性虫卵抗原致敏对树突状细胞功能的影响[J]. 咸宁医学院学报, 2006, 20(1): 20-22 |
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| 作者姓名： | 段新文 |
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| 作者单位： | 咸宁卫生学校,湖北咸宁437100 |
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| 摘 要： | 目的探讨日本血吸虫可溶性虫卵抗原(SEA)致敏对树突状细胞(DC)功能的影响.方法利用SEA致敏DC,流武细胞术(FACS)检测SEA致敏的DC摄取抗原的能力,混合淋巴细胞反应检测SEA致敏的DC对同种异体T淋巴细胞的刺激作用.结果与未致敏的DC相比,SEA致敏后,DC摄取抗原的能力无明显变化,SEA致敏的DC抑制混合淋巴细胞反应.结论体外SEA致敏DC后,不是促进DC的活化,而是抑制DC的生物学活性.
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| 关 键 词： | 树突状细胞 致敏 可溶性虫卵抗原 |
| 文章编号： | 1008-0635(2006)01-0020-03 |
| 收稿时间： | 2005-11-05 |
| 修稿时间： | 2005-11-05 |
Effect of Soluble Egg Antigen of Schistosoma Japonicum Pulsing on the Functions of Dendritic Cell in Vitro |
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| DUAN Xin-wen. Effect of Soluble Egg Antigen of Schistosoma Japonicum Pulsing on the Functions of Dendritic Cell in Vitro[J]. Journal of Xianning Medical College, 2006, 20(1): 20-22 |
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| Authors: | DUAN Xin-wen |
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| Affiliation: | Xianning Health School, Xianning Hubei 437100, China |
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| Abstract: | Objective To explore the effect of soluble egg antigen of Schistosoma japonicum(SEA) on the functions of dendritic cell(DC) in vitro.Methods DC were sensitized by SEA.The antigen in-taking ability of DC was determined by FACS.The mixed lymphocyte reaction was used to detect the effect of SEA sensitized DC on stimulating allogenic T lymphocyte.Results Compared to untreated DC,the antigen in-taking ability had no significant change in SEA sensitized DC but the latter could inhibit the proliferation of allogenic T cells.Conclusion SEA sensitization can not promote DC activation,but inhibit the biologic activity of DC. |
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| Keywords: | Dendritic cell Sensitization Soluble egg antigen |
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