毛细支气管炎患儿血清乳酸脱氢酶水平的变化及临床意义

目的探讨毛细支气管炎患儿血清乳酸脱氢酶(LDH)水平及其临床意义。方法将131例毛细支气管炎患儿按临床症状分为重症组和轻症组两组,并与正常对照组进行比较。结果与正常对照组比较,毛细支气管炎患儿LDH显著升高(P<0.05);入院时,轻症组与重症组LDH分别为316.3±84.6 IU/L、567.8±101.5 IU/L(P<0.05),经过1周治疗后轻症组与重症组LDH分别为188.6±59.5 IU/L、195.4±63.3 IU/L(P<0.05);而且治疗1周后轻症组临床症状均缓解,而重症组有7例患儿临床症状无缓解甚至加重,LDH水平进一步升高。结论毛细支气管炎患儿血清LDH的改变可以提示临床症状轻重,对预后判断也具有临床意义。

Detection of serum lactic dehydrogenase of infants with bronchiolitis and its clinical significance

Objective To investigate the level of serum lactic dehydrogenase（LDH）of infants with bronchiolitis and its clinical significance.Methods According to the clinical manifestation,131 infant cases with bronchiolitis were divided into two groups,severe case group（group S） and mild case group（group M）.Serum lactic dehydrogenase was detected by automatic biochemistry analyzer and compared between bronchiolitis cases and control subjects.Results Compared with control group,the infants with bronchiolitis had higher LDH level（P0.05）.On admission,LDH was 316.3±84.6 IU/L in group M and 567.8±101.5 IU/L in group S（P0.05）,and it was 188.6±59.5 IU/L and 195.4±63.3 IU/L respectively after one week treatment（P0.05）.Moreover,all cases in group M had remission,but 7 cases in group S did not have remission or even aggravated and accompanied by further elevated LDH.Conclusion The changes of LDH level in infants with bronchiolitis may indicate the severity of clinical symptoms,and it makes a significant contribution to evaluate the prognosis of bronchiolitis.