检测慢性肝病患者血清BMP2和BMP4的临床价值

目的研究慢性肝病患者血清中的骨形态发生蛋白2(BMP2)和骨形态发生蛋白4(BMP4)的表达,了解两者在诊断和鉴别诊断原发性肝癌(PHC)中的临床价值。方法按照病理学诊断或者临床资料诊断,对住院的60例患者进行分组,PHC组25例,肝硬化组17例,肝炎组18例。9例健康对照组采自同期健康体检者。分别检测各组患者及正常者血清甲胎蛋白(AFP)、BMP2和BMP4。结果①PHC组患者血清中的BMP2较健康对照组、肝炎组、肝硬化组低,差异都有统计学意义(P<0.05)。②PHC组患者血清BMP4较其余3组组低,差异都有统计学意义(P<0.01)。③BMP2诊断PHC的敏感性为92.00%,特异性为100%,准确率是97.10%;BMP4诊断PHC的敏感性为80.00%,特异性为100%,准确率为92.75%。结论 BMP2、BMP4对PHC的诊断和鉴别诊断具有一定的价值。

Clinical significance of serum BMP2 and BMP4 in patients with chronic hepatitis virus infection

Objective To study the significance of serum bone morphogenetic protein 2（BMP2） and bone morphogenetic protein 4（BMP4） in diagnosis and differential diagnosis of primary hepatic carcinoma（PHC）.Methods Blood samples were drawn from 60 inpatients.According to their pathological diagnosis or clinical diagnosis,they were divided into three groups： 25 in primary hepatic carcinoma group,17 in hepatic cirrhosis group and 18 in chronic hepatitis group.The control blood samples were collected from 9 healthy persons in health examination department.The serum levels of AFP,BMP2 and BMP4 were detected in all these groups.Results ① The serum levels of BMP2 in PHC patients were lower than those of normal controls and patients with chronic hepatitis and hepatic cirrhosis.（P0.05）.② The serum levels of BMP4 in patients with PHC were lower than those in other groups.（P0.05）.③ The sensitivity,specificity and veracity of serum BMP2 in diagnosis of PHC were 92.00%,100% and 97.10% respectively.The sensitivity,specificity and veracity of serum BMP4 in diagnosis of PHC were 80.00%,100% and 92.75% respectively.Conclusion There is certain value of serum BMP2 and BMP4 in diagnosis and differential diagnosis of PHC.