高血压病主要危险因素的Meta分析

目的研究中国居民高血压病的主要影响因素,探讨预防对策。方法通过检索中国知网收集2000年至2011年4月发表的所有与高血压病危险因素相关的病例对照研究,并采用Meta分析方法对纳入研究的结果进行定量合并分析,计算其合并危险因素暴露的比值比(OR值)及95%可信区间(CI)。结果共纳入11篇文献,研究了饮酒、吸烟、体质指数(BMI)、高血压家族史、盐摄入量、文化程度、经济状况等危险因素与高血压病之间的联系。其中BMI、高血压家族史、盐摄入量、吸烟、饮酒、经济状况与高血压病相关,其OR(95%CI)分别为2.45(2.09,2.87)、2.01(1.92,2.11)、1.68(1.23,2.28)、1.58(1.50,1.66)、2.17(2.04,2.31)及2.57(1.89,3.48)。结论 BMI、高血压家族史、盐摄入量、吸烟、饮酒、经济状况与高血压病相关,是高血压病发生的主要危险因素。

A meta-analysis on risk factors of hypertension

Objective To identify the risk factors of hypertension in China in order to find the way for prevention.Methods All hypertension-related case-control studies published in CNKI from 2000 to April 2011were applied for meta-analysis to calculate the pooled OR and 95%CI.Results Eleven studies were included in which the relationship between hypertension and risk factors such as drinking,smoking,BMI,family history of hypertension,high salt intake,literacy and income were assessed.The results of meta-analysis indicated that hypertension had close relationship with BMI,family history of hypertension,high salt intake,smoking,drinking and income.Their pooled OR and 95%CI were 2.45（2.09,2.87）,2.01（1.92,2.11）,1.68（1.23,2.28）,1.58（1.50,1.66）,2.17（2.04,2.31） and 2.57（1.89,3.48） respectively.Conclusion Overweight,family history of hypertension,high salt intake,smoking,drinking and income have close relationship with hypertension,and they are risk factors in pathogenesis of hypertension.