| 肿瘤多药耐药的产生机制及逆转策略 |
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| 引用本文： | 吴静,杨睿,刘树业.肿瘤多药耐药的产生机制及逆转策略[J].国外医学(肿瘤学分册),2013(12):889-892. |
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| 作者姓名： | 吴静 杨睿 刘树业 |
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| 作者单位： | [1]天津市第三中心医院检验科,300170 [2]天津医科大学基础医学研究中心转化肿瘤学实验室,300170 |
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| 基金项目： | 国家自然科学基金（81301985） |
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| 摘 要： | 肿瘤多药耐药（MDR）是导致临床化疗失败和患者死亡的主要原因。研究表明，MDR的发生与P-糖蛋白、多药耐药相关蛋白、乳腺癌耐药相关蛋白、肺耐药相关蛋白等多种因素相关。目前MDR的逆转策略主要包括化学药物逆转、基因逆转、免疫逆转、中药逆转和纳米载药系统逆转，并且均取得了一定进展，这将有助于提高肿瘤患者的化疗疗效。
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| 关 键 词： | 肿瘤 抗药性，多药 纳米技术 |
Mechanisms and reversal strategies of tumor multidrug resistance |
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| WU Jing,YANG Rui,LIU Shu-ye.Mechanisms and reversal strategies of tumor multidrug resistance[J].Foreign Medical Sciences (Cancer Section),2013(12):889-892. |
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| Authors: | WU Jing YANG Rui LIU Shu-ye |
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| Institution: | . Department of Clinical Laboratory, Tianjin Third Central Hospital, Tianjin 300170, China |
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| Abstract: | Tumor muhidrug resistance （MDR） is the leading cause of clinical chemotherapy failure and death. Researches show that the occurrence of MDR is related to P-glycoprotein, muhidrug resistance-asso- ciated proteins, breast cancer resistance-associated proteins, lung resistance-related proteins and other factors. Now the reversal strategies of MDR include chemical drugs reversal, gene reversal, immune reversal, traditional Chinese medicine reversal and drug-loaded nano-system reversal, which make some progress and help to improve the effect of cancer chemotherapy. |
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| Keywords: | Neoplasms Drug resistance multiple Nanotechnology |
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