首发未服药精神分裂症患者血清血管内皮生长因子水平的研究

目的探讨首发未服药精神分裂症患者血清血管内皮生长因子(VEGF)水平。方法选取2014年10月-2015年10月就诊于宁波市康宁医院的符合《国际疾病分类(第10版)》(ICD-10)诊断标准的首发未服药精神分裂症患者73例为研究组,采用阳性和阴性症状量表(PANSS)评定其精神症状的严重程度;选取与研究组性别、年龄及BMI相匹配的60例健康人为对照组,采用酶联免疫吸附法测定两组血清VEGF水平。结果研究组和对照组血清VEGF水平差异有统计学意义[(351.96±85.31)pg/m L vs.(280.98±77.54)pg/m L,P0.01]。精神分裂症患者组血清VEGF水平与PANSS评分、年龄和BMI无线性相关(P0.05)。结论首发未服药精神分裂症患者血清VEGF水平稍高于健康对照组,精神分裂症患者血清VEGF与PANSS评分、年龄和BMI无关联。

Serum vascular endothelial growth factor levels in drug - naive patients with first - episode schizophrenia

Objective To investigate the serum vascular endothelial growth factor(VEGF)levels in drug - naive patients with first- episode schizophrenia. Methods The study group enrolled 73 drug - naive patients with first - episode schizophrenia from Ningbo Kangning Hospital,from October 2014 to October 2015,who met the diagnostic criteria of International Classification of Diseases, tenth edition( ICD - 10)for schizophrenia. Positive and Negative Symptoms Scale( PANSS)was used to evaluate the severity of psychopathological symptoms in schizophrenia patients. 60 healthy subjects(control group)matched with the study group in terms of gender,age and body mass index(BMI)were recruited. The serum VEGF levels in the two groups were analyzed by enzyme - linked immunosorbent assay. Results The study group had a significant increase in the serum VEGF levels than that in the control group [(351. 96 ±85. 31)pg/ mL vs.(280. 98 ± 77. 54)pg/ mL,P < 0. 01]. There was no significant correlation between the serum VEGF levels with PANSS scores,age or BMI(P >0.05). Conclusion It suggests that the serum VEGF levels increase in drug -naive patients with first -episode schizophrenia compared to healthy controls. There is no significant correlation between serum VEGF and PANSS scores,age or BMI in schizophrenia patients.