比索洛尔和美托洛尔治疗223例慢性充血性心力衰竭的疗效比较

目的:比较比索洛尔和美托洛尔治疗慢性充血性心力衰竭的疗效。方法:233例慢性充血性心力衰竭病人随机分为比索洛尔组和美托洛尔组。比索洛尔组(116例)每日口服比索洛尔2.5～10mg,美托洛尔组(117例)每日口服美托洛尔25～100mg。共治疗2a。结果:比索洛尔组临床总有效率为72.4％,美托洛尔组临床总有效率为70.1％(临床心功能与用药前相比均P<0.01)。2组用药后超声心动图测得的左室收缩功能均明显改善(P<0.01)。2组死亡率、心血管疾病死亡率及心血管疾病住院次数无明显差别。结论:比索洛尔和美托洛尔均对治疗慢性充血性心力衰竭有效。

Effects of bisoprolol and metoprolol in 223 patients with chronic congestive heart failure

AIM:To evaluate the effects of bisoprolol and metoprolol in the treatment of chronic congestive heart failure.METHODS:Two hundred and thirty-three patients with chronic congestive heart failure patients were randomized into bisoprolol group and metoprolol group.Patients were treated with bisoprolol 2.5-10mg.d~(-1)or metoprolol 25-100mg.d~(-1)orally in bisoprolol group(116 patients)and metoprolol group (117 patients)for 2 years,respectively.RESULTS:The total effective rate of bisoprolol group was 72.4% and total effective rate of metoprolol group was 70.1%.There was significant difference of heart function before and after treatment(P<0.01).Left ventricular systolic function by echocardiogram improved remarkably in both groups(P<0.01).The total mortality,cardiovascular mortality and cardiovascular disease hospital admission were no difference between 2 groups.CONCLUSION:Both bisoprolol and metoprolol are beneficial for the treatment of chronic congestive heart failure.