强心饮对心衰病模型大鼠心功能及心肌肥厚影响的实验研究

目的：观察强心饮对阿霉素诱导的心肌肥厚大鼠相关调控细胞生长与增殖蛋白表达的变化，以探讨强心饮对心肌肥厚潜在的作用机制。方法40只SD大鼠随机分为5组：模型组、正常组、雷帕霉素组、强心饮大剂量组、强心饮小剂量组。采取腹腔注射阿霉素复制大鼠心肌肥厚模型，观察大鼠心肌形态学、血流动力学、心衰指标及调控心肌肥厚相关蛋白表达的变化。结果与模型组比较，强心饮治疗组明显改善心肌肥厚大鼠心脏结构及功能，降低心肌组织BNP含量，抑制调控细胞生长蛋白mTOR及p70S6K的磷酸化（P＜0.01或P＜0.05）。结论强心饮能改善心肌肥厚大鼠心功能及抑制心肌肥厚，其机制可能调控p-mTOR及p-p70S6K的表达有关。

Experimental Study on the Effect of Qiangxin Decoction on the Cardiac Function and Cardiac Hypertrophy in Rats with Heart Failure

Objective To observe the effects of Qiangxin decoction on protein expression of regulation cell growth and proliferation in Rats with Adriamycin （ADR）-induced cardiac hypertrophy,and to investigate potential molecular mechanisms of cardiac hypertrophy. Methods Forty Sprague Dawley rats were randomly divided as follows：ADR group,normal control group, rapamycin treatment group,high and low dosage Qiangxin decoction groups. The morphology,hemodynamic,brain natriuretic peptide, and relative protein expression of cardiac hypertrophy were observed. Results Compared with ADR group, Qiangxin decoction treatment significantly inhibited the extent of the cardiac hypertrophy,improved cardiac function,while the expression level of phosphorylated mTOR （p-mTOR）and phosphorylated p70S6K （p- p70S6K）significantly reduced. Conclusion The present study demonstrated that Qiangxin decoction significantly relieve the myocardial hypertrophy and improve the cardiac function,The protective effect of the derivatives could be due to the inhibition of the activities of p-mTOR and p-p70S6K.