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氟西汀与丙咪嗪治疗抑郁症的临床对照研究
引用本文:邹来英,陈光金,潘玉凤,侯爱芝,廉鹏. 氟西汀与丙咪嗪治疗抑郁症的临床对照研究[J]. 精神医学杂志, 2002, 15(2): 89-90
作者姓名:邹来英  陈光金  潘玉凤  侯爱芝  廉鹏
作者单位:山东泰安市精神卫生中心 271000(邹来英,陈光金,潘玉凤,侯爱芝),山东泰安市精神卫生中心 271000(廉鹏)
摘    要:目的:研究氟西汀与丙咪嗪治疗抑郁症的临床疗效和副反应。方法:对42例符合CCMD-2-R诊断标准的重性抑郁症住院患者,随机分组,分别用氟西汀和丙咪嗪治疗6周,用汉密尔顿抑郁量表(HAMD)和临床疗效总评量表(CGI)评定临床疗效,用副反应量表(TESS)评定副反应。结果:氟西汀组显效率85.7%,丙咪嗪组显效率为76.2%,两得无明显差异(P>0.05),氟西汀组副作用较丙咪嗪组少而轻。结论:氟西汀治疗抑郁症疗效好,副反应少而轻。

关 键 词:氟西汀 丙咪嗪 治疗 抑郁症 对照研究

A comparative study of fluoxetine and imipramine in the treatment of depression.
Zou Laiying,Chen Guangjin,Pan Yufeng,et al.. A comparative study of fluoxetine and imipramine in the treatment of depression.[J]. Journal of Psychiatry, 2002, 15(2): 89-90
Authors:Zou Laiying  Chen Guangjin  Pan Yufeng  et al.
Affiliation:Zou Laiying,Chen Guangjin,Pan Yufeng,et al. Taian Mental Health Center,Taian 271000
Abstract:Objective To determine the efficacy and side effects of fluoxetine in the treatment of patients with depression . Methods 42 patients who met the CCMD - 2 - R criteria of major depression were randomly divided into research (fluoxetine) and control (imipramine) groups for the treatment of 6 weeks.The efficacy were assessed by Hamilton Depression Rating Scale (HAMD) and Clinical Global Impression( CGI) ,and the side effects were assessed by Treatment E-mergent Symptoms Scale (TESS) .Results There was no significant difference in the efficacy (P > 0.05) .The response rate was 85.7% and 76.2% for fluoxetine and imipramine respectively, while fluoxetine had less side effects. Conclusion Fluoxetine is an effective antidepressant with less side effects compared with imipramine.
Keywords:Fluoxetine Imipramine Depression
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