正常人脑葡萄糖代谢标准数据库建立

目的利用Scenium软件研究不同年龄正常人脑葡萄糖代谢,建立正常人脑葡萄糖代谢标准数据库。方法收集318例健康体检者的脑PET图像,按年龄分7组。用Scenium软件进行图像归一化并勾划脑区,得到不同年龄段各脑区SUV平均值后进行分析。结果建立正常人脑葡萄糖代谢标准数据库。本数据库显示各脑区葡萄糖代谢随年龄增加呈递减趋势,31-40岁、51-60岁年龄段明显;减低显著脑区有额叶、颞叶、岛叶、扣带回及基底节,左侧较明显;小脑、杏仁核、海马及海马旁回减低不明显。结论正常人脑功能代谢随年龄增加呈非匀速性、非对称性减低。不同年龄段正常人脑葡萄糖代谢标准数据库为功能性脑疾病PET诊断提供客观依据。

Establishment of a Normal Brain ^18F-FDG PET/CT Database

Objective To establish the normal cerebral glucose metabolism database in different ages by using ^18F-FDG PET/CT and Scenium software. Methods ^18F-FDG PET/CT brain imaging data acquired from 318 healthy normal subjects were divided into 7 groups. The brain areas were automatically outlined by Scenium and the mean SUV value of each area was calculated at the same time. Then the group mean value of each brain area was calculated and analyzed. Results Cerebral glucose metabolism decreased with age increase, in particular, 31-40y and 51-60y groups. The areas that decreased most were frontal lobe, temporal lobe, insula, cinglulate gyrus and basal ganglia, especially the left side, while the lest ones were cerebellum, amygdala, hippocampus and parahippocampal gyrus. The normal ^18 F-FDG PET/CT database was established. Conclusion Cerebral glucose metabolism of normal decreases unevenly and asymmetrically, mainly involving frontal lobe, temporal lobe, insula, cinglulate gyrus and basal ganglia, while cerebellum, amygdala, hippocampus and parahippocampal gyrus were less involved. The database provided objective basis for the diagnosis of brain function disease in PET/CT.